There are 7 ways to get from Mobile to Des Moines by plane, train, bus, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Mobile Regional Airport
best- Fly from Mobile Regional Airport (MOB) to Des Moines (DSM)plane MOB - DSM
8h 5m$177–761Bus to Pensacola International Airport, fly
cheapest- Take the bus from Mobile Bus Station to Pensacola Airportbus
- Fly from Pensacola International Airport (PNS) to Des Moines (DSM)plane PNS - DSM
8h 36m$166–738Train, bus
- Take the train from Mobile, AL to New Orleans, LA - Union Passenger Terminaltrain
- Take the bus from New Orleans Bus Station to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Des Moinesbus
28h 48m$205–419Train, bus via Champaign
- Take the train from Mobile, AL to New Orleans, LA - Union Passenger Terminaltrain
- Take the train from New Orleans Union Passenger Terminal to Champaign-Urbanatrain
- Take the bus from Champaign Intermodal Trans Ctr to Des Moinesbus
30h 8m$340–739Drive 957.6 mi
- Drive from Mobile to Des Moinescar 957.6 mi
18h 6m$175–253Train to Gulfport-Biloxi Regional Airport, fly
- Take the train from Mobile Amtrak Sta to Gulfport Amtrak Statrain
- Fly from Gulfport-Biloxi Regional Airport (GPT) to Des Moines (DSM)plane GPT - DSM
7h 40m$255–1,036Bus to Destin–Fort Walton Beach Airport, fly
- Take the bus from Mobile to Crestviewbus
- Fly from Destin–Fort Walton Beach Airport (VPS) to Des Moines (DSM)plane VPS - DSM
8h 4m$266–897
Mobile Regional Airport (MOB) to Des Moines (DSM) flights
Questions & Answers
The cheapest way to get from Mobile to Des Moines is to drive which costs $170 - $260 and takes 18h 6m.
The fastest way to get from Mobile to Des Moines is to train and fly which takes 7h 40m and costs $250 - $1,100.
The distance between Mobile and Des Moines is 842 miles. The road distance is 963.2 miles.
The best way to get from Mobile to Des Moines without a car is to train and bus which takes 28h 48m and costs $200 - $420.
It takes approximately 8h 5m to get from Mobile to Des Moines, including transfers.
Yes, the driving distance between Mobile to Des Moines is 963 miles. It takes approximately 18h 6m to drive from Mobile to Des Moines.
There are 262+ hotels available in Des Moines.
What companies run services between Mobile, AL, USA and Des Moines, IA, USA?
Delta, American Airlines, and United Airlines fly from Mobile Regional Airport (MOB) to Des Moines (DSM) every 3 hours.
- Website
- aa.com
Flights from Mobile Regional Airport to Des Moines via Dallas/Ft.Worth
- Ave. Duration
- 6h 54m
- When
- Every day
- Estimated price
- $170–800
Flights from Mobile Regional Airport to Des Moines via Charlotte
- Ave. Duration
- 5h 56m
- When
- Every day
- Estimated price
- $190–850
Flights from Gulfport-Biloxi Regional Airport to Des Moines via Dallas/Ft.Worth
- Ave. Duration
- 7h 1m
- When
- Every day
- Estimated price
- $200–950
Flights from Gulfport-Biloxi Regional Airport to Des Moines via Charlotte
- Ave. Duration
- 5h 54m
- When
- Every day
- Estimated price
- $240–1,100
Flights from Destin–Fort Walton Beach Airport to Des Moines via Dallas/Ft.Worth
- Ave. Duration
- 7h 5m
- When
- Every day
- Estimated price
- $180–850
Flights from Destin–Fort Walton Beach Airport to Des Moines via Chicago O'Hare
- Ave. Duration
- 7h 49m
- When
- Every day
- Estimated price
- $160–800
Flights from Pensacola International Airport to Des Moines via Dallas/Ft.Worth
- Ave. Duration
- 6h 33m
- When
- Every day
- Estimated price
- $160–750
Flights from Pensacola International Airport to Des Moines via Chicago O'Hare
- Ave. Duration
- 9h 21m
- When
- Every day
- Estimated price
- $150–700
- Website
- delta.com
Flights from Mobile Regional Airport to Des Moines via Atlanta
- Ave. Duration
- 5h 11m
- When
- Every day
- Estimated price
- $160–750
Flights from Gulfport-Biloxi Regional Airport to Des Moines via Atlanta
- Ave. Duration
- 7h 13m
- When
- Every day
- Estimated price
- $200–950
Flights from Destin–Fort Walton Beach Airport to Des Moines via Atlanta
- Ave. Duration
- 4h 59m
- When
- Every day
- Estimated price
- $150–750
Flights from Destin–Fort Walton Beach Airport to Des Moines via Minneapolis
- Ave. Duration
- 6h 48m
- When
- Every day
- Estimated price
- $180–850
Flights from Pensacola International Airport to Des Moines via Atlanta
- Ave. Duration
- 5h 21m
- When
- Every day
- Estimated price
- $140–700
- Website
- united.com
Flights from Mobile Regional Airport to Des Moines via Houston
- Ave. Duration
- 5h 20m
- When
- Every day
- Estimated price
- $180–850
Flights from Mobile Regional Airport to Des Moines via Washington Dulles, Chicago O'Hare
- Ave. Duration
- 8h 49m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $230–1,000
Flights from Gulfport-Biloxi Regional Airport to Des Moines via Houston
- Ave. Duration
- 5h 8m
- When
- Monday, Thursday, Friday, Tuesday, Wednesday, and Sunday
- Estimated price
- $210–1,000
Flights from Pensacola International Airport to Des Moines via Houston
- Ave. Duration
- 5h 26m
- When
- Tuesday, Wednesday, Thursday, Friday, Monday, and Sunday
- Estimated price
- $170–800
Flights from Pensacola International Airport to Des Moines via Chicago O'Hare
- Ave. Duration
- 7h 13m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $150–700
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Mobile, AL to New Orleans, LA - Union Passenger Terminal
- Ave. Duration
- 3h 43m
- Frequency
- Twice daily
- Estimated price
- $30–90
- Website
- https://www.amtrak.com/home.html
Train from Mobile, AL to New Orleans, LA - Union Passenger Terminal
- Ave. Duration
- 3h 43m
- Frequency
- Twice daily
- Estimated price
- $30–90
- Website
- https://www.amtrak.com/home.html
Train from New Orleans Union Passenger Terminal to Champaign-Urbana
- Ave. Duration
- 16h 40m
- Frequency
- Once daily
- Estimated price
- $260–550
- Website
- https://www.amtrak.com/home.html
Train from Mobile Amtrak Sta to Gulfport Amtrak Sta
- Ave. Duration
- 1h 39m
- Frequency
- Twice daily
- Estimated price
- $23–50
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from New Orleans Bus Station to St Louis Bus Station
- Ave. Duration
- 14h 40m
- Frequency
- Once daily
- Estimated price
- $110–210
- Website
- https://www.greyhound.com/
Bus from St Louis Bus Station to Des Moines
- Ave. Duration
- 8h 25m
- Frequency
- Once daily
- Estimated price
- $65–120
- Website
- https://www.greyhound.com/
Bus from Champaign Intermodal Trans Ctr to Des Moines
- Ave. Duration
- 7h 45m
- Frequency
- Once daily
- Estimated price
- $50–100
- Website
- https://www.greyhound.com/
Bus from Mobile Bus Station to Pensacola Airport
- Ave. Duration
- 1h 5m
- Frequency
- Twice daily
- Estimated price
- $9–18
- Website
- https://www.greyhound.com/
- Phone
- +1 800-923-1799
- [email protected]
- Website
- omnibusexpress.com
Bus from Mobile to Crestview
- Ave. Duration
- 1h 43m
- Frequency
- Once daily
- Estimated price
- $45–65
- Schedules at
- omnibusexpress.com
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