There are 8 ways to get from Mobile to Florence by plane, bus (Greyhound), train (Amtrak), car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Mobile Regional Airport to Florence Regional Airport
best- Fly from Mobile Regional Airport (MOB) to Florence Regional Airport (FLO)plane MOB - FLO
8h 38m$81–377Bus to Pensacola International Airport, fly to Florence Regional Airport
cheapest- Take the bus from Mobile Bus Station to Pensacola Airportbus
- Fly from Pensacola International Airport (PNS) to Florence Regional Airport (FLO)plane PNS - FLO
9h 40m$80–352Bus
- Take the bus from Mobile Bus Station to Atlanta Bus Stationbus Greyhound US0602 / ...
- Take the bus from Atlanta Bus Station to Florence Bus Stationbus Greyhound US0642 / ...
15h 17m$131–206Train (Amtrak)
- Take the train from Mobile, AL to New Orleans, LA - Union Passenger Terminaltrain
- Take the train from New Orleans Union Passenger Terminal to Greensborotrain
- Take the train from Greensboro to Selma Stationtrain
- Take the train from Selma Station to Florence Stationtrain
32h 57m$385–854Drive 611.7 mi
- Drive from Mobile to Florencecar 611.7 mi
10h 2m$112–162Fly Mobile Regional Airport to Myrtle Beach, bus
- Fly from Mobile Regional Airport (MOB) to Myrtle Beach (MYR)plane MOB - MYR
- Take the bus from Myrtle Beach to Florencebus
9h 45m$111–382Bus via Mobile
- Take the bus from Mobile to Atlantabus Houston
- Take the bus from Atlanta Bus Station to Florence Bus Stationbus Greyhound US0642 / ...
15h 18m$162–242Bus via Sumter
- Take the bus from Mobile Bus Station to Atlanta Bus Stationbus
- Take the bus from Atlanta to Sumterbus
- Take the bus from Sumter Bus Stop to Florence Bus Stationbus
15h 32m$172–240
Mobile to Florence by bus
Questions & Answers
The cheapest way to get from Mobile to Florence is to drive which costs $110 - $170 and takes 10h 2m.
The fastest way to get from Mobile to Florence is to fly which takes 8h 38m and costs $80 - $380.
No, there is no direct bus from Mobile to Florence station. However, there are services departing from St Joseph SB Near St Louis St and arriving at Florence Bus Station via Mobile Bus Station and Atlanta Bus Station. The journey, including transfers, takes approximately 15h 17m.
No, there is no direct train from Mobile to Florence station. However, there are services departing from Mobile, AL and arriving at Florence Station via New Orleans Union Passenger Terminal, Greensboro and Selma Station. The journey, including transfers, takes approximately 32h 57m.
The distance between Mobile and Florence is 581 miles. The road distance is 615.3 miles.
The best way to get from Mobile to Florence without a car is to bus which takes 15h 17m and costs $130 - $210.
It takes approximately 8h 38m to get from Mobile to Florence, including transfers.
Mobile to Florence bus services, operated by Greyhound USA, depart from Mobile Bus Station.
Mobile to Florence train services, operated by Amtrak, depart from Mobile, AL station.
The best way to get from Mobile to Florence is to fly which takes 8h 38m and costs $80 - $380. Alternatively, you can bus, which costs $130 - $210 and takes 15h 17m, you could also train, which costs $380 - $900 and takes 32h 57m.
What companies run services between Mobile, AL, USA and Florence, SC, USA?
American Airlines flies from Mobile Regional Airport (MOB) to Florence Regional Airport (FLO) 5 times a day. Alternatively, you can take a bus from St Joseph SB Near St Louis St to Florence Bus Station via Govt WB Across from Greyhound, Mobile Bus Station, and Atlanta Bus Station in around 15h 17m.
- Website
- aa.com
Flights from Mobile Regional Airport to Florence Regional Airport via Charlotte
- Ave. Duration
- 7h 7m
- When
- Every day
- Estimated price
- $70–370
Flights from Mobile Regional Airport to Florence Regional Airport via Dallas/Ft.Worth, Charlotte
- Ave. Duration
- 9h 29m
- When
- Every day
- Estimated price
- $130–600
Flights from Pensacola International Airport to Florence Regional Airport via Charlotte
- Ave. Duration
- 6h 58m
- When
- Every day
- Estimated price
- $60–320
Flights from Mobile Regional Airport to Myrtle Beach via Charlotte
- Ave. Duration
- 5h 4m
- When
- Every day
- Estimated price
- $60–330
- Website
- delta.com
Flights from Mobile Regional Airport to Myrtle Beach via Atlanta
- Ave. Duration
- 4h 20m
- When
- Every day
- Estimated price
- $60–320
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Mobile, AL to New Orleans, LA - Union Passenger Terminal
- Ave. Duration
- 3h 43m
- Frequency
- Twice daily
- Estimated price
- $30–90
- Website
- https://www.amtrak.com/home.html
Train from New Orleans Union Passenger Terminal to Greensboro
- Ave. Duration
- 21h 12m
- Frequency
- Once daily
- Estimated price
- $280–600
- Website
- https://www.amtrak.com/home.html
Train from Greensboro to Selma Station
- Ave. Duration
- 2h 22m
- Frequency
- Once daily
- Estimated price
- $35–75
- Website
- https://www.amtrak.com/home.html
Train from Selma Station to Florence Station
- Ave. Duration
- 2h 40m
- Frequency
- Once daily
- Estimated price
- $40–90
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Mobile Bus Station to Atlanta Bus Station
- Ave. Duration
- 5h 35m
- Frequency
- 5 times a day
- Estimated price
- $50–110
- Website
- https://www.greyhound.com/
Bus from Atlanta Bus Station to Florence Bus Station
- Ave. Duration
- 6h 20m
- Frequency
- Twice daily
- Estimated price
- $50–95
- Website
- https://www.greyhound.com/
Bus from Mobile Bus Station to Pensacola Airport
- Ave. Duration
- 1h 5m
- Frequency
- Twice daily
- Estimated price
- $10–19
- Website
- https://www.greyhound.com/
Bus from Atlanta Bus Station to Florence Bus Station
- Ave. Duration
- 6h 20m
- Frequency
- Twice daily
- Estimated price
- $50–95
- Website
- https://www.greyhound.com/
Bus from Mobile Bus Station to Atlanta Bus Station
- Ave. Duration
- 5h 35m
- Frequency
- 5 times a day
- Estimated price
- $50–110
- Website
- https://www.greyhound.com/
Bus from Sumter Bus Stop to Florence Bus Station
- Ave. Duration
- 55 min
- Frequency
- Once daily
- Estimated price
- $6–12
- Website
- https://www.greyhound.com/
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Mobile Bus Station to Atlanta Bus Station
- Ave. Duration
- 6h
- Frequency
- 5 times a day
- Estimated price
- $80–120
- Book at
- https://www.jeffersonlines.com
- Adult
- $80–120
Bus from Atlanta Bus Station to Florence Bus Station
- Ave. Duration
- 7h 5m
- Frequency
- 3 times a day
- Estimated price
- $75–110
- Book at
- https://www.jeffersonlines.com
- Adult
- $75–110
Bus from Myrtle Beach to Florence
- Ave. Duration
- 1h 35m
- Frequency
- Once daily
- Estimated price
- $27–40
- Book at
- https://www.jeffersonlines.com
- Adult
- $27–40
Bus from Atlanta Bus Station to Florence Bus Station
- Ave. Duration
- 7h 5m
- Frequency
- 3 times a day
- Estimated price
- $75–110
- Book at
- https://www.jeffersonlines.com
- Adult
- $75–110
Bus from Mobile Bus Station to Atlanta Bus Station
- Ave. Duration
- 6h
- Frequency
- 5 times a day
- Estimated price
- $80–120
- Book at
- https://www.jeffersonlines.com
- Adult
- $80–120
Bus from Atlanta to Sumter
- Ave. Duration
- 5h 25m
- Frequency
- Once daily
- Estimated price
- $70–100
- Book at
- https://www.jeffersonlines.com
- Adult
- $70–100
Bus from Sumter Bus Stop to Florence Bus Station
- Ave. Duration
- 55 min
- Frequency
- Once daily
- Estimated price
- $21–29
- Book at
- https://www.jeffersonlines.com
- Adult
- $21–29
- Phone
- +1 800-923-1799
- [email protected]
- Website
- omnibusexpress.com
Bus from Mobile to Atlanta
- Ave. Duration
- 5h 6m
- Frequency
- Once daily
- Estimated price
- $70–95
- Schedules at
- omnibusexpress.com
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More Questions & Answers
Mobile to Florence bus services, operated by Greyhound USA, arrive at Atlanta Bus Station.
Florence is 1h ahead of Mobile. It is currently 6:16 PM in Mobile and 7:16 PM in Florence.
Mobile to Florence train services, operated by Amtrak, arrive at New Orleans, LA - Union Passenger Terminal station.
Yes, the driving distance between Mobile to Florence is 615 miles. It takes approximately 10h 2m to drive from Mobile to Florence.
Book your Mobile to Florence train tickets online with Omio.
Book your Mobile to Florence bus tickets online with Omio.
There are 48+ hotels available in Florence.










