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How to get fromMobile to Florenceby plane, bus (Greyhound), train (Amtrak), car, or bus

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There are 6 ways to get from Mobile to Florence by plane, bus (Greyhound), train (Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Florence Regional Airport

    best
    1. Fly from Mobile Regional Airport (MOB) to Florence Regional Airport (FLO)plane plane MOB - FLO
    5h 15m
    $107–430

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Mobile Bus Station to Atlanta Bus Stationbus bus Greyhound US0602 / ...
    2. Take the bus from Atlanta Bus Station to Florence Bus Stationbus bus Greyhound US0641S / ...
    14h 11m
    $99–164

  3. Train (Amtrak)

    1. Take the train from Mobile, AL to New Orleans, LA - Union Passenger Terminaltrain train
    2. Take the train from New Orleans Union Passenger Terminal to Greensborotrain train
    3. Take the train from Greensboro to Selma Stationtrain train
    4. Take the train from Selma Station to Florence Stationtrain train
    32h 57m
    $640–1,081

  4. Drive  611.7 mi

    1. Drive from Mobile to Florencecar car 611.7 mi
    10h 2m
    $112–162

  5. Fly to Myrtle Beach, bus

    1. Fly from Mobile Regional Airport (MOB) to Myrtle Beach (MYR)plane plane MOB - MYR
    2. Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus bus
    7h 19m
    $114–419

  6. Bus via Mobile

    1. Take the bus from Mobile to Atlantabus bus Houston
    2. Take the bus from Atlanta Bus Station to Florence Bus Stationbus bus Greyhound US0641S / ...
    14h 34m
    $157–227

Mobile to Florence by bus (Greyhound)

Calendar14Weekly Buses
Duration14h 11mAverage Duration
Ticket$99Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mobile to Florence.ExpandLaunch map view
  • Distance: 567.9 mi
  • Duration: 5h 15m

What companies run services between Mobile, AL, USA and Florence, SC, USA?

American Airlines flies from Mobile Regional Airport (MOB) to Florence Regional Airport (FLO) 4 times a day. Alternatively, you can take a bus from Water St SB and St Louis St to Florence Bus Station via Govt WB Across from Greyhound, Mobile Bus Station, and Atlanta Bus Station in around 14h 11m.

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Need to know: Greyhound

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