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How to get fromMobile to Florida Keysby plane, bus (Greyhound), car, bus, or train

Find Transport to Florida Keys

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There are 7 ways to get from Mobile to Florida Keys by plane, bus (Greyhound), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Mobile Regional Airport

    best
    1. Fly from Mobile Regional Airport (MOB) to Key West International Airport (EYW)plane plane MOB - EYW
    9h 23m
    $179–501

  2. Bus to Pensacola International Airport, fly

    cheapest
    1. Take the bus from Mobile Bus Station to Pensacola Airportbus bus
    2. Fly from Pensacola International Airport (PNS) to Key West International Airport (EYW)plane plane PNS - EYW
    10h 19m
    $137–409

  3. Bus

    1. Take the bus from Mobile to Miamibus bus Houston
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus Greyhound US0720s
    21h 54m
    $164–216

  4. Drive  843.2 mi

    1. Drive from Mobile to Florida Keyscar car 843.2 mi
    15h 6m
    $154–223

  5. Bus to Destin–Fort Walton Beach Airport, fly

    1. Take the bus from Mobile to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW)plane plane VPS - EYW
    9h 54m
    $231–540

  6. Train to Gulfport-Biloxi Regional Airport, fly

    1. Take the train from Mobile Amtrak Sta to Gulfport Amtrak Statrain train
    2. Fly from Gulfport-Biloxi Regional Airport (GPT) to Key West International Airport (EYW)plane plane GPT - EYW
    10h 7m
    $189–574

  7. Bus via Tallahassee (Greyhound)

    1. Take the bus from Mobile Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    27h 41m
    $148–243

Mobile to Florida Keys by bus and foot (Greyhound)

Calendar7Weekly Services
Duration27h 41mAverage Duration
Ticket$148Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mobile to Florida Keys.ExpandLaunch map view
  • Distance: 614.7 mi
  • Duration: 9h 23m

What companies run services between Mobile, AL, USA and Florida Keys, FL, USA?

Delta and American Airlines fly from Mobile Regional Airport (MOB) to Key West International Airport (EYW) 5 times a day. Alternatively, you can take a bus from Mobile to Florida Keys via Miami, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 21h 54m.

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