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How to get fromMobile to Great Smoky Mountainsby bus, plane, or car

Find Transport to Great Smoky Mountains

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There are 7 ways to get from Mobile to Great Smoky Mountains by bus, plane, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Destin–Fort Walton Beach Airport, fly to Mcghee Tyson Airport, drive

    best
    1. Take the bus from Mobile to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS)plane plane VPS - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    6h 24m
    $209–742

  2. Fly Mobile Regional Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from Mobile Regional Airport (MOB) to Asheville Regional Airport (AVL)plane plane MOB - AVL
    2. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    8h 35m
    $74–353

  3. Bus, drive

    1. Take the bus from Mobile Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte Bus Station to Asheville, NCbus bus
    4. Drive from Asheville, NC to Great Smoky Mountainscar car
    17h 29m

  4. Drive 512.1 mi

    1. Drive from Mobile to Great Smoky Mountainscar car 512.1 mi
    9h 15m
    $94–135

  5. Fly Mobile Regional Airport to Mcghee Tyson Airport, drive

    1. Fly from Mobile Regional Airport (MOB) to Mcghee Tyson Airport (TYS)plane plane MOB - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    8h 21m
    $117–615

  6. Bus to Pensacola International Airport, fly to Mcghee Tyson Airport, drive

    1. Take the bus from Mobile Bus Station to Pensacola Airportbus bus
    2. Fly from Pensacola International Airport (PNS) to Mcghee Tyson Airport (TYS)plane plane PNS - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    8h 43m
    $109–584

  7. Bus, drive via Mobile

    1. Take the bus from Mobile to Atlantabus bus
    2. Take the bus from Atlanta Downtown to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte Bus Station to Asheville, NCbus bus
    4. Drive from Asheville, NC to Great Smoky Mountainscar car
    17h 57m

Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS) flights

Calendar21Weekly Planes
Duration2h 46mAverage Duration
Ticket$99Cheapest Price
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Questions & Answers

Map of how to get from Mobile to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 589 mi
  • Duration: 6h 24m

What companies run services between Mobile, AL, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Mobile to Great Smoky Mountains. However, you can take the bus to Crestview, take the taxi to Destin–Fort Walton Beach Airport (VPS) airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take a bus from St Joseph SB Near St Louis St to Great Smoky Mountains via Govt WB Across from Greyhound, Mobile Bus Station, Atlanta Bus Station, Charlotte Bus Station, and Asheville, NC in around 17h 29m.

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