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How to get fromMobile to Knoxvilleby plane, bus, taxi, shuttle, car, or train

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There are 5 ways to get from Mobile to Knoxville by plane, bus, taxi, shuttle, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Mobile Regional Airport

    best
    1. Fly from Mobile Regional Airport (MOB) to Mcghee Tyson Airport (TYS)plane plane MOB - TYS
    3h 51m
    $227–1,007

  2. Drive  508.2 mi

    cheapest
    1. Drive from Mobile to Knoxvillecar car 508.2 mi
    8h 17m
    $93–134

  3. Bus, taxi, shuttle, drive

    1. Take the bus from Mobile Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte to Boonebus bus
    4. Take the taxi from Boone to Black Bear Resorttaxi taxi
    5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    6. Drive from Hot Springs to Chilhowee at Holstoncar car
    21h 54m
    $381–484

  4. Bus to Destin–Fort Walton Beach Airport, fly

    1. Take the bus from Mobile to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS)plane plane VPS - TYS
    4h 48m
    $284–1,046

  5. Train to Gulfport-Biloxi Regional Airport, fly

    1. Take the train from Mobile Amtrak Sta to Gulfport Amtrak Statrain train
    2. Fly from Gulfport-Biloxi Regional Airport (GPT) to Mcghee Tyson Airport (TYS)plane plane GPT - TYS
    6h 23m
    $259–1,049

Mobile Regional Airport (MOB) to Mcghee Tyson Airport (TYS) flights

Calendar61Weekly Planes
Duration4h 51mAverage Duration
Ticket$144Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Mobile to Knoxville.ExpandLaunch map view
  • Distance: 456.9 mi
  • Duration: 3h 51m

What companies run services between Mobile, AL, USA and Knoxville, TN, USA?

Delta, American Airlines, and United Airlines fly from Mobile Regional Airport (MOB) to Mcghee Tyson Airport (TYS) every 3 hours.

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