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How to get fromMobile to Knoxvilleby plane, train, taxi, bus, shuttle, or car

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There are 6 ways to get from Mobile to Knoxville by plane, train, taxi, bus, shuttle, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Mobile Regional Airport

    best
    1. Fly from Mobile Regional Airport (MOB) to Mcghee Tyson Airport (TYS)plane plane MOB - TYS
    6h 47m
    $174–756

  2. Drive 508.2 mi

    cheapest
    1. Drive from Mobile to Knoxvillecar car 508.2 mi
    8h 17m
    $93–134

  3. Train, taxi, bus, shuttle, drive

    1. Take the train from Mobile, AL to New Orleans, LA - Union Passenger Terminaltrain train
    2. Take the train from New Orleans Union Passenger Terminal to Charlotte Amtrak Stationtrain train
    3. Take the taxi from Davidson Gateway Dr & Griffith St to Hickory Airporttaxi taxi
    4. Take the bus from Hickory Airport to Blowing Rock - Tanger Outletsbus bus
    5. Take the taxi from Blowing Rock - Tanger Outlets to Black Bear Resorttaxi taxi
    6. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    7. Drive from Hot Springs to Knoxvillecar car
    33h 25m
    $744–1,164

  4. Bus to Destin–Fort Walton Beach Airport, fly

    1. Take the bus from Mobile to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS)plane plane VPS - TYS
    4h 48m
    $264–896

  5. Train to Gulfport-Biloxi Regional Airport, fly

    1. Take the train from Mobile Amtrak Sta to Gulfport Amtrak Statrain train
    2. Fly from Gulfport-Biloxi Regional Airport (GPT) to Mcghee Tyson Airport (TYS)plane plane GPT - TYS
    6h 45m
    $241–983

  6. Bus to Pensacola International Airport, fly

    1. Take the bus from Mobile Bus Station to Pensacola Airportbus bus
    2. Fly from Pensacola International Airport (PNS) to Mcghee Tyson Airport (TYS)plane plane PNS - TYS
    7h 9m
    $164–687

Mobile Regional Airport (MOB) to Mcghee Tyson Airport (TYS) flights

Calendar69Weekly Planes
Duration5h 1mAverage Duration
Ticket$118Cheapest Price
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Questions & Answers

Map of how to get from Mobile to Knoxville.ExpandLaunch map view
  • Distance: 466.2 mi
  • Duration: 6h 47m

What companies run services between Mobile, AL, USA and Knoxville, TN, USA?

Delta, American Airlines, and United Airlines fly from Mobile Regional Airport (MOB) to Mcghee Tyson Airport (TYS) every 3 hours.

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