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How to get fromMobile to Knoxvilleby plane, bus, taxi, shuttle, car, or train

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There are 5 ways to get from Mobile to Knoxville by plane, bus, taxi, shuttle, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Mobile Regional Airport

    best
    1. Fly from Mobile Regional Airport (MOB) to Mcghee Tyson Airport (TYS)plane plane MOB - TYS
    4h 23m
    $207–857

  2. Drive  508.2 mi

    cheapest
    1. Drive from Mobile to Knoxvillecar car 508.2 mi
    8h 17m
    $93–134

  3. Bus, taxi, shuttle, drive

    1. Take the bus from Mobile Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte to Boonebus bus
    4. Take the taxi from Boone to Black Bear Resorttaxi taxi
    5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    6. Drive from Hot Springs to Chilhowee at Holstoncar car
    21h 44m
    $374–473

  4. Bus to Destin–Fort Walton Beach Airport, fly

    1. Take the bus from Mobile to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS)plane plane VPS - TYS
    4h 48m
    $264–896

  5. Train to Gulfport-Biloxi Regional Airport, fly

    1. Take the train from Mobile Amtrak Sta to Gulfport Amtrak Statrain train
    2. Fly from Gulfport-Biloxi Regional Airport (GPT) to Mcghee Tyson Airport (TYS)plane plane GPT - TYS
    6h 43m
    $229–980

Mobile Regional Airport (MOB) to Mcghee Tyson Airport (TYS) flights

Calendar68Weekly Planes
Duration5h 10mAverage Duration
Ticket$124Cheapest Price
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Questions & Answers

Map of how to get from Mobile to Knoxville.ExpandLaunch map view
  • Distance: 456.9 mi
  • Duration: 4h 23m

What companies run services between Mobile, AL, USA and Knoxville, TN, USA?

Delta, American Airlines, and United Airlines fly from Mobile Regional Airport (MOB) to Mcghee Tyson Airport (TYS) every 3 hours.

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