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How to get fromMobile to Knoxvilleby bus, plane, taxi, shuttle, car, or train

Find Transport to Knoxville

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There are 6 ways to get from Mobile to Knoxville by bus, plane, taxi, shuttle, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Destin–Fort Walton Beach Airport, fly

    best
    1. Take the bus from Mobile to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS)plane plane VPS - TYS
    4h 48m
    $264–896

  2. Drive  508.2 mi

    cheapest
    1. Drive from Mobile to Knoxvillecar car 508.2 mi
    8h 17m
    $93–134

  3. Bus, taxi, shuttle, drive

    1. Take the bus from Mobile Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte to Boonebus bus
    4. Take the taxi from Boone to Black Bear Resorttaxi taxi
    5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    6. Drive from Hot Springs to Chilhowee at Holstoncar car
    22h 5m
    $374–473

  4. Fly from Mobile Regional Airport

    1. Fly from Mobile Regional Airport (MOB) to Mcghee Tyson Airport (TYS)plane plane MOB - TYS
    7h 11m
    $179–798

  5. Train to Gulfport-Biloxi Regional Airport, fly

    1. Take the train from Mobile Amtrak Sta to Gulfport Amtrak Statrain train
    2. Fly from Gulfport-Biloxi Regional Airport (GPT) to Mcghee Tyson Airport (TYS)plane plane GPT - TYS
    6h 43m
    $229–980

  6. Bus to Pensacola International Airport, fly

    1. Take the bus from Mobile Bus Station to Pensacola Airportbus bus
    2. Fly from Pensacola International Airport (PNS) to Mcghee Tyson Airport (TYS)plane plane PNS - TYS
    7h 9m
    $175–785

Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS) flights

Calendar20Weekly Planes
Duration2h 21mAverage Duration
Ticket$115Cheapest Price
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Questions & Answers

Map of how to get from Mobile to Knoxville.ExpandLaunch map view
  • Distance: 542.6 mi
  • Duration: 4h 48m

What companies run services between Mobile, AL, USA and Knoxville, TN, USA?

Delta, American Airlines, and United Airlines fly from Mobile Regional Airport (MOB) to Mcghee Tyson Airport (TYS) every 3 hours.

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