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How to get fromMobile to Knoxvilleby bus, plane, train, taxi, shuttle, or car

Find Transport to Knoxville

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There are 6 ways to get from Mobile to Knoxville by bus, plane, train, taxi, shuttle, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Destin–Fort Walton Beach Airport, fly

    best
    1. Take the bus from Mobile to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS)plane plane VPS - TYS
    4h 49m
    $249–796

  2. Drive 508.2 mi

    cheapest
    1. Drive from Mobile to Knoxvillecar car 508.2 mi
    8h 17m
    $93–134

  3. Train, taxi, bus, shuttle, drive

    1. Take the train from Mobile, AL to New Orleans, LA - Union Passenger Terminaltrain train
    2. Take the train from New Orleans Union Passenger Terminal to Charlotte Amtrak Stationtrain train
    3. Take the taxi from Davidson Gateway Dr & Griffith St to Hickory Airporttaxi taxi
    4. Take the bus from Hickory Airport to Blowing Rock - Tanger Outletsbus bus
    5. Take the taxi from Blowing Rock - Tanger Outlets to Black Bear Resorttaxi taxi
    6. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    7. Drive from Hot Springs to Knoxvillecar car
    33h 25m
    $774–1,227

  4. Fly from Mobile Regional Airport

    1. Fly from Mobile Regional Airport (MOB) to Mcghee Tyson Airport (TYS)plane plane MOB - TYS
    6h 41m
    $160–666

  5. Train to Gulfport-Biloxi Regional Airport, fly

    1. Take the train from Mobile Amtrak Sta to Gulfport Amtrak Statrain train
    2. Fly from Gulfport-Biloxi Regional Airport (GPT) to Mcghee Tyson Airport (TYS)plane plane GPT - TYS
    6h 45m
    $223–935

  6. Bus to Pensacola International Airport, fly

    1. Take the bus from Mobile Bus Station to Pensacola Airportbus bus
    2. Fly from Pensacola International Airport (PNS) to Mcghee Tyson Airport (TYS)plane plane PNS - TYS
    7h 5m
    $154–637

Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS) flights

Calendar26Weekly Planes
Duration2h 39mAverage Duration
Ticket$97Cheapest Price
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Questions & Answers

Map of how to get from Mobile to Knoxville.ExpandLaunch map view
  • Distance: 542.6 mi
  • Duration: 4h 49m

What companies run services between Mobile, AL, USA and Knoxville, TN, USA?

Delta, American Airlines, and United Airlines fly from Mobile Regional Airport (MOB) to Mcghee Tyson Airport (TYS) every 2 hours.

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