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How to get fromMobile to Lafayetteby bus, plane, shuttle, bus (Greyhound, Amtrak), train (Amtrak), or car

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There are 6 ways to get from Mobile to Lafayette by bus, plane, shuttle, bus (Greyhound, Amtrak), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Destin–Fort Walton Beach Airport, fly, shuttle

    best
    1. Take the bus from Mobile to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Indianapolis (IND)plane plane VPS - IND
    3. Take a shuttle bus from Indianapolis Airport to Holiday Inn City Centreshuttle bus
    6h 54m
    $213–711

  2. Bus to Pensacola International Airport, fly, shuttle

    cheapest
    1. Take the bus from Mobile Bus Station to Pensacola Airportbus bus
    2. Fly from Pensacola International Airport (PNS) to Indianapolis (IND)plane plane PNS - IND
    3. Take a shuttle bus from Indianapolis Airport to Holiday Inn City Centreshuttle bus
    9h 3m
    $108–523

  3. Bus

    1. Take the bus from Mobile Bus Station to Montgomery Intermodal Centerbus bus
    2. Take the bus from Montgomery Intermodal Center to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Lafayette Amtrak Stationbus bus
    21h 37m
    $130–274

  4. Train (Amtrak)

    1. Take the train from Mobile, AL to New Orleans, LA - Union Passenger Terminaltrain train
    2. Take the train from New Orleans Union Passenger Terminal to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    28h 14m
    $365–820

  5. Drive 774 mi

    1. Drive from Mobile to Lafayettecar car 774 mi
    13h 56m
    $142–204

  6. Fly from Mobile Regional Airport, shuttle

    1. Fly from Mobile Regional Airport (MOB) to Indianapolis (IND)plane plane MOB - IND
    2. Take a shuttle bus from Indianapolis Airport to Holiday Inn City Centreshuttle bus
    9h 29m
    $126–599

Mobile to Lafayette by bus

Calendar7Weekly Buses
Duration21h 37mAverage Duration
Ticket$130Cheapest Price
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Questions & Answers

Map of how to get from Mobile to Lafayette.ExpandLaunch map view
  • Distance: 840.2 mi
  • Duration: 6h 54m

What companies run services between Mobile, AL, USA and Lafayette, IN, USA?

You can take a bus from St Joseph SB Near St Louis St to Lafayette Amtrak Station via Govt WB Across from Greyhound, Mobile Bus Station, Montgomery Intermodal Center, and Indianapolis Union Station in around 21h 37m. Alternatively, you can take a train from Mobile, AL to Lafayette Amtrak Station via New Orleans Union Passenger Terminal and Chicago Union Station in around 28h 14m.

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