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How to get fromMobile to Louisvilleby plane, bus (Greyhound), car, bus, or train

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There are 6 ways to get from Mobile to Louisville by plane, bus (Greyhound), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Mobile Regional Airport to Louisville International Airport

    best
    1. Fly from Mobile Regional Airport (MOB) to Louisville International Airport (SDF)plane plane MOB - SDF
    5h 11m
    $143–740

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Mobile Bus Station to Montgomery Intermodal Centerbus bus Greyhound US0602 / ...
    2. Take the bus from Montgomery Intermodal Center to Louisville Bus Stationbus bus Greyhound US0112
    16h 3m
    $102–172

  3. Drive  598.1 mi

    1. Drive from Mobile to Louisvillecar car 598.1 mi
    10h 59m
    $110–158

  4. Fly Mobile Regional Airport to Blue Grass Airport, drive

    1. Fly from Mobile Regional Airport (MOB) to Blue Grass Airport (LEX)plane plane MOB - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 24m
    $110–436

  5. Bus to Destin–Fort Walton Beach Airport, fly to Louisville International Airport

    1. Take the bus from Mobile to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Louisville International Airport (SDF)plane plane VPS - SDF
    6h 7m
    $200–779

  6. Train to Gulfport-Biloxi Regional Airport, fly to Louisville International Airport

    1. Take the train from Mobile Amtrak Sta to Gulfport Amtrak Statrain train
    2. Fly from Gulfport-Biloxi Regional Airport (GPT) to Louisville International Airport (SDF)plane plane GPT - SDF
    7h 44m
    $163–813

Mobile to Louisville by bus (Greyhound)

Calendar7Weekly Buses
Duration16h 3mAverage Duration
Ticket$102Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mobile to Louisville.ExpandLaunch map view
  • Distance: 557 mi
  • Duration: 5h 11m

What companies run services between Mobile, AL, USA and Louisville, KY, USA?

Delta, United Airlines, and American Airlines fly from Mobile Regional Airport (MOB) to Louisville International Airport (SDF) every 2 hours. Alternatively, you can take a bus from Govt WB and Joachim St to Louisville Bus Station via Govt WB Across from Greyhound, Mobile Bus Station, and Montgomery Intermodal Center in around 16h 3m.

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