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How to get fromMobile to Louisvilleby plane, bus (Greyhound, Amtrak), car, bus, train, or bus (Greyhound)

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There are 7 ways to get from Mobile to Louisville by plane, bus (Greyhound, Amtrak), car, bus, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Mobile Regional Airport to Louisville International Airport

    best
    1. Fly from Mobile Regional Airport (MOB) to Louisville International Airport (SDF)plane plane MOB - SDF
    5h 34m
    $153–740

  2. Drive  598.1 mi

    cheapest
    1. Drive from Mobile to Louisvillecar car 598.1 mi
    10h 59m
    $110–158

  3. Bus

    1. Take the bus from Mobile Bus Station to Montgomery Intermodal Centerbus bus
    2. Take the bus from Montgomery Intermodal Center to Nashville Bus Stationbus bus
    3. Take the bus from Nashville to Louisville, KYbus bus
    14h 48m
    $111–170

  4. Fly Mobile Regional Airport to Blue Grass Airport, drive

    1. Fly from Mobile Regional Airport (MOB) to Blue Grass Airport (LEX)plane plane MOB - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 36m
    $110–436

  5. Bus to Destin–Fort Walton Beach Airport, fly to Louisville International Airport

    1. Take the bus from Mobile to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Louisville International Airport (SDF)plane plane VPS - SDF
    6h 7m
    $210–829

  6. Train to Gulfport-Biloxi Regional Airport, fly to Louisville International Airport

    1. Take the train from Mobile Amtrak Sta to Gulfport Amtrak Statrain train
    2. Fly from Gulfport-Biloxi Regional Airport (GPT) to Louisville International Airport (SDF)plane plane GPT - SDF
    7h 36m
    $185–832

  7. Bus via Preston @ Vim

    1. Take the bus from Mobile Bus Station to Montgomery Intermodal Centerbus bus
    2. Take the bus from Montgomery Intermodal Center to Nashville Bus Stationbus bus
    3. Take the bus from Tornado Bus Co - Nashville to La Tropicana - Louisville, KYbus bus
    15h 42m
    $119–185

Mobile to Louisville by bus

Calendar14Weekly Buses
Duration14h 48mAverage Duration
Ticket$111Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mobile to Louisville.ExpandLaunch map view
  • Distance: 557 mi
  • Duration: 5h 34m

What companies run services between Mobile, AL, USA and Louisville, KY, USA?

Delta, American Airlines, and United Airlines fly from Mobile Regional Airport (MOB) to Louisville International Airport (SDF) every 2 hours. Alternatively, you can take a bus from Govt WB and Joachim St to Louisville, KY via Govt WB Across from Greyhound, Mobile Bus Station, Montgomery Intermodal Center, and Nashville in around 14h 48m.

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