There are 3 ways to get from Mobile to Sanibel Island by plane, bus, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Mobile Regional Airport (MOB) to Ft. Myers (RSW) flights
Comparing Your Travel Options
The cheapest way to get from Mobile to Sanibel Island is to drive which costs $110 - $170 and takes 11h 3m.
The fastest way to get from Mobile to Sanibel Island is to fly which takes 5h and costs $190 - $650.
No, there is no direct bus from Mobile to Sanibel Island. However, there are services departing from Mobile and arriving at Fort Myers via . The journey, including transfers, takes approximately 12h 35m.
The distance between Mobile and Sanibel Island is 527 miles. The road distance is 625.3 miles.
The best way to get from Mobile to Sanibel Island without a car is to bus which takes 12h 35m and costs $160 - $210.
It takes approximately 5h to get from Mobile to Sanibel Island, including transfers.
Mobile to Sanibel Island bus services, operated by Omnibus Express, depart from Mobile station.
The best way to get from Mobile to Sanibel Island is to fly which takes 5h and costs $190 - $650. Alternatively, you can bus, which costs $160 - $210 and takes 12h 35m.
Mobile to Sanibel Island bus services, operated by Omnibus Express, arrive at Fort Myers station.
Yes, the driving distance between Mobile to Sanibel Island is 625 miles. It takes approximately 11h 3m to drive from Mobile to Sanibel Island.
What companies run services between Mobile, AL, USA and Sanibel Island, FL, USA?
Delta and American Airlines fly from Mobile Regional Airport (MOB) to Ft. Myers (RSW) every 4 hours. Alternatively, Omnibus Express operates a bus from Mobile to Fort Myers once daily. Tickets cost $110–140 and the journey takes 12h 4m.
- Website
- delta.com
Flights from Mobile Regional Airport to Ft. Myers via Atlanta
- Ave. Duration
- 4h 56m
- When
- Every day
- Estimated price
- $95–500
- Website
- aa.com
Flights from Mobile Regional Airport to Ft. Myers via Charlotte
- Ave. Duration
- 5h 34m
- When
- Every day
- Estimated price
- $110–600
Flights from Mobile Regional Airport to Ft. Myers via Dallas/Ft.Worth
- Ave. Duration
- 7h 15m
- When
- Every day
- Estimated price
- $150–700
- Phone
- +1 800-923-1799
- [email protected]
- Website
- Omnibus Express
Bus from Mobile to Fort Myers
- Ave. Duration
- 12h 4m
- Frequency
- Once daily
- Estimated price
- $110–140
- Schedules at
- Omnibus Express
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Booking & Getting There
There are 4313+ hotels available in Sanibel Island.


