There are 8 ways to get from Moline to Cape Girardeau by plane, taxi, train, bus, car, or bus (Greyhound, Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Quad City International Airport to Williamson County Regional Airport, taxi
best- Fly from Quad City International Airport (MLI) to Williamson County Regional Airport (MWA)plane MLI - MWA
- Take the taxi from Williamson County Regional Airport (MWA) to Cape Girardeautaxi
6h 35m$191–531Drive 353.7 mi
cheapest- Drive from Moline to Cape Girardeaucar 353.7 mi
6h 29m$65–94Taxi, train
- Take the taxi from Moline to Galesburg Amtrak Stationtaxi
- Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Carbondaletrain
- Take the taxi from Carbondale to Cape Girardeautaxi
11h 19m$354–569Bus, taxi
- Take the bus from Moline Center Station to Chicago Bus Stationbus
- Take the bus from Chicago to Anna - Shellbus
- Take the taxi from Anna - Shell to Cape Girardeautaxi
12h 45m$170–226Fly Quad City International Airport to Barkley Regional Airport, taxi
- Fly from Quad City International Airport (MLI) to Barkley Regional Airport (PAH)plane MLI - PAH
- Take the taxi from Barkley Regional Airport (PAH) to Cape Girardeautaxi
7h 54m$201–531Bus to Chicago O'Hare International Airport, fly to Williamson County Regional Airport, taxi
- Take the bus from Moline Center Station to Chicago Bus Stationbus
- Fly from Chicago O'Hare International Airport (ORD) to Williamson County Regional Airport (MWA)plane ORD - MWA
- Take the taxi from Williamson County Regional Airport (MWA) to Cape Girardeautaxi
8h 48m$239–428Bus, train
- Take the bus from Moline Center Station to Chicago Bus Stationbus
- Take the train from Chicago Union Station to St. Louistrain
- Take the bus from St Louis Bus Station to Cape Girardeaubus
13h 14m$121–240Bus
- Take the bus from Moline Center Station to Chicago Bus Stationbus
- Take the bus from Chicago Bus Station to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Cape Girardeaubus
14h 14m$96–150
Quad City International Airport (MLI) to Williamson County Regional Airport (MWA) flights
Comparing Your Travel Options
The cheapest way to get from Moline to Cape Girardeau is to drive which costs $60 - $95 and takes 6h 29m.
The fastest way to get from Moline to Cape Girardeau is to drive which takes 6h 29m and costs $60 - $95.
No, there is no direct bus from Moline station to Cape Girardeau. However, there are services departing from Moline Center Station and arriving at Cape Girardeau via Chicago Bus Station and St Louis Bus Station. The journey, including transfers, takes approximately 14h 14m.
The distance between Moline and Cape Girardeau is 333 miles. The road distance is 355.7 miles.
The best way to get from Moline to Cape Girardeau without a car is to taxi and train which takes 11h 19m and costs $350 - $600.
It takes approximately 6h 35m to get from Moline to Cape Girardeau, including transfers.
Moline to Cape Girardeau bus services, operated by Greyhound USA, depart from Moline Center Station.
Moline to Cape Girardeau bus services, operated by Greyhound USA, arrive at Chicago Bus Station.
Yes, the driving distance between Moline to Cape Girardeau is 356 miles. It takes approximately 6h 29m to drive from Moline to Cape Girardeau.
Book your Moline to Cape Girardeau bus tickets online with Omio.
What companies run services between Moline, IL, USA and Cape Girardeau, MO, USA?
You can take a bus from Moline Center Station to Cape Girardeau via Chicago Bus Station, St Louis Bus Station, and Cape Girardeau in around 14h 14m.
- Website
- aa.com
Flights from Quad City International Airport to Williamson County Regional Airport via Chicago O'Hare International Airport
- Ave. Duration
- 5h 23m
- When
- Every day
- Estimated price
- $60–370
Flights from Quad City International Airport to Williamson County Regional Airport via Charlotte, Chicago O'Hare International Airport
- Ave. Duration
- 7h 59m
- When
- Every day
- Estimated price
- $140–650
Flights from Chicago O'Hare International Airport to Williamson County Regional Airport
- Ave. Duration
- 1h 22m
- When
- Every day
- Estimated price
- $45–300
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Galesburg Amtrak Station to Chicago Union Station
- Ave. Duration
- 2h 55m
- Frequency
- 3 times a day
- Estimated price
- $40–95
- Website
- Amtrak
Train from Chicago Union Station to Carbondale
- Ave. Duration
- 5h 30m
- Frequency
- 3 times a day
- Estimated price
- $75–180
- Website
- Amtrak
Train from Chicago Union Station to St. Louis
- Ave. Duration
- 4h 46m
- Frequency
- 5 times a day
- Estimated price
- $70–160
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Moline Center Station to Chicago Bus Station
- Ave. Duration
- 4h 10m
- Frequency
- 3 times a day
- Estimated price
- $27–45
- Website
- Greyhound
Bus from Moline Center Station to Chicago Bus Station
- Ave. Duration
- 4h 10m
- Frequency
- 3 times a day
- Estimated price
- $27–45
- Website
- Greyhound
Bus from Moline Center Station to Chicago Bus Station
- Ave. Duration
- 4h 10m
- Frequency
- 3 times a day
- Estimated price
- $27–45
- Website
- Greyhound
Bus from St Louis Bus Station to Cape Girardeau
- Ave. Duration
- 2h 5m
- Frequency
- Once daily
- Estimated price
- $17–28
- Website
- Greyhound
Bus from Moline Center Station to Chicago Bus Station
- Ave. Duration
- 4h 10m
- Frequency
- 3 times a day
- Estimated price
- $27–45
- Website
- Greyhound
Bus from St Louis Bus Station to Cape Girardeau
- Ave. Duration
- 2h 5m
- Frequency
- Once daily
- Estimated price
- $17–28
- Website
- Greyhound
- Ave. Duration
- 1h 4m
- Estimated price
- $70–170
Ace Taxi
- Phone
- +1 216-361-4700
- Website
- acetaxi.com
Dana's Cabs
- Phone
- +1 563-323-2227
- Website
- danascabs.com
Good to Go Taxi Cab Service
- Phone
- +1 563-424-2039
- Website
- goodtogotaxi.com
Larry's Cab
- Phone
- +1 563-388-7179
Ace Taxi
- Phone
- +1 216-361-4700
- Website
- acetaxi.com
Ace Taxi
- Phone
- +1 216-361-4700
- Website
- acetaxi.com
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Booking & Getting There
There are 25+ hotels available in Cape Girardeau.








