There are 7 ways to get from Monroeville to Knoxville by bus, plane, train, car, bus (Greyhound), or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus, bus to Pittsburgh International Airport, fly to Mcghee Tyson Airport
best- Take the bus from Monroeville Blvd + Brinton to Liberty Ave + 10Th St Nsbus
- Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus
- Fly from Pittsburgh International Airport (PIT) to Mcghee Tyson Airport (TYS)plane PIT - TYS
7h 26mDrive 488.2 mi
cheapest- Drive from Monroeville to Knoxvillecar 488.2 mi
8h 24m$90–129Train, bus
- Take the train from Pittsburgh Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain Pennsylvanian
- Take the bus from New York, NY to Knoxville, TNbus Ny
24h 54m$277–450Train to Johnstown-Cambria County Airport, fly to Mcghee Tyson Airport
- Take the train from Pittsburgh Amtrak Station to Johnstown Amtrak Stationtrain
- Fly from Johnstown-Cambria County Airport (JST) to Mcghee Tyson Airport (TYS)plane JST - TYS
8h 59m$203–788Fly Pittsburgh International Airport to Nashville, drive
- Fly from Pittsburgh International Airport (PIT) to Nashville (BNA)plane PIT - BNA
- Drive from Nashville-Airport-BNA to Knoxvillecar
7h 48m$550–1,048Bus via Farragut
- Take the bus from Pittsburgh Intermodal Station to Port Authority Bus Terminalbus Greyhound US0421 / ...
- Take the bus from New York to Knoxvillebus Nyc
25h 14m$250–379Bus
- Take the bus from Pittsburgh Intermodal Station to New York City Chinatownbus FlixBus N2640
- Take the bus from New York, NY to Knoxville, TNbus Ny
28h 27m$171–233
Pittsburgh International Airport (PIT) to Mcghee Tyson Airport (TYS) flights
Questions & Answers
The cheapest way to get from Monroeville to Knoxville is to drive which costs $85 - $130 and takes 8h 24m.
The fastest way to get from Monroeville to Knoxville is to fly and drive which takes 7h 48m and costs $550 - $1,100.
No, there is no direct bus from Monroeville to Knoxville. However, there are services departing from Monroeville Blvd + Brinton and arriving at Knoxville via Pittsburgh Intermodal Station and New York. The journey, including transfers, takes approximately 25h 14m.
The distance between Monroeville and Knoxville is 442 miles. The road distance is 491 miles.
The best way to get from Monroeville to Knoxville without a car is to train and bus which takes 24h 54m and costs $270 - $450.
It takes approximately 7h 26m to get from Monroeville to Knoxville, including transfers.
Monroeville to Knoxville bus services, operated by Greyhound USA, depart from Pittsburgh Intermodal Station.
Monroeville to Knoxville bus services, operated by Greyhound USA, arrive at Port Authority Bus Terminal station.
Yes, the driving distance between Monroeville to Knoxville is 491 miles. It takes approximately 8h 24m to drive from Monroeville to Knoxville.
There are 271+ hotels available in Knoxville.
What companies run services between Monroeville, PA, USA and Knoxville, TN, USA?
You can take a bus from Monroeville Blvd + Brinton to Knoxville via East Busway + Penn Station C, Pittsburgh Intermodal Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 25h 14m.
- Website
- delta.com
Flights from Pittsburgh International Airport to Mcghee Tyson Airport via Atlanta
- Ave. Duration
- 4h 25m
- When
- Every day
- Estimated price
- $150–800
Flights from Pittsburgh International Airport to Mcghee Tyson Airport via Detroit
- Ave. Duration
- 4h 32m
- When
- Every day
- Estimated price
- $140–800
Flights from Pittsburgh International Airport to Nashville via Detroit
- Ave. Duration
- 3h 45m
- When
- Every day
- Estimated price
- $90–480
Flights from Pittsburgh International Airport to Nashville via Atlanta
- Ave. Duration
- 3h 58m
- When
- Every day
- Estimated price
- $95–500
- Website
- southwest.com
Flights from Pittsburgh International Airport to Mcghee Tyson Airport via Nashville
- Ave. Duration
- 4h 45m
- When
- Saturday, Monday, Thursday, and Friday
- Estimated price
- $140–750
Flights from Pittsburgh International Airport to Mcghee Tyson Airport via Baltimore
- Ave. Duration
- 4h 21m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $150–800
Flights from Pittsburgh International Airport to Nashville
- Ave. Duration
- 1h 34m
- When
- Every day
- Estimated price
- $75–430
Flights from Pittsburgh International Airport to Nashville via Chicago Midway
- Ave. Duration
- 3h 40m
- When
- Monday, Thursday, and Friday
- Estimated price
- $100–550
- Website
- aa.com
Flights from Pittsburgh International Airport to Mcghee Tyson Airport via Reagan Washington
- Ave. Duration
- 4h 36m
- When
- Every day
- Estimated price
- $140–800
Flights from Pittsburgh International Airport to Mcghee Tyson Airport via Charlotte
- Ave. Duration
- 4h 31m
- When
- Every day
- Estimated price
- $130–750
- Website
- united.com
Flights from Pittsburgh International Airport to Mcghee Tyson Airport via Washington Dulles
- Ave. Duration
- 4h 25m
- When
- Every day
- Estimated price
- $140–750
Flights from Johnstown-Cambria County Airport to Mcghee Tyson Airport via Washington Dulles
- Ave. Duration
- 6h 3m
- When
- Monday, Thursday, Friday, Sunday, and Wednesday
- Estimated price
- $110–650
Flights from Johnstown-Cambria County Airport to Mcghee Tyson Airport via Chicago O'Hare
- Ave. Duration
- 6h 35m
- When
- Every day
- Estimated price
- $160–800
- Website
- allegiantair.com
Flights from Pittsburgh International Airport to Nashville
- Ave. Duration
- 1h 33m
- When
- Thursday and Sunday
- Estimated price
- $75–430
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Pittsburgh Amtrak Station to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 9h 20m
- Frequency
- Once daily
- Estimated price
- $130–290
- Website
- Amtrak
Train from Pittsburgh Amtrak Station to Johnstown Amtrak Station
- Ave. Duration
- 1h 32m
- Frequency
- Once daily
- Estimated price
- $24–50
- Website
- Amtrak
- Phone
- +1 412-442-2000
- Website
- Pittsburgh Regional Transit
Bus from Monroeville Blvd + Brinton to Liberty Ave + 10Th St Ns
- Ave. Duration
- 58 min
- Frequency
- Hourly
- Website
- Pittsburgh Regional Transit
Bus from Seventh Ave + Smithfield St to Pittsburgh International Airport
- Ave. Duration
- 43 min
- Frequency
- Every 30 minutes
- Website
- Pittsburgh Regional Transit
- Phone
- +1 615-939-8887
- [email protected]
- Website
- New York to Tennessee Bus
Bus from New York, NY to Knoxville, TN
- Ave. Duration
- 12h
- Frequency
- Once daily
- Estimated price
- $95–110
- Website
- New York to Tennessee Bus
- Adult One-way
- $95–110
Bus from New York, NY to Knoxville, TN
- Ave. Duration
- 12h
- Frequency
- Once daily
- Estimated price
- $95–110
- Website
- New York to Tennessee Bus
- Adult One-way
- $95–110
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Pittsburgh Intermodal Station to Port Authority Bus Terminal
- Ave. Duration
- 9h 40m
- Frequency
- Every 2 hours
- Estimated price
- $65–130
- Website
- Greyhound
- Phone
- +1 646-630-7186
- [email protected]
- Website
- Wanda Coach
Bus from New York to Knoxville
- Ave. Duration
- 11h 45m
- Frequency
- Once daily
- Estimated price
- $95–140
- Website
- Wanda Coach
- Book at
- GotoBus.com
- Adult One Way
- $95–140
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Pittsburgh Intermodal Station to New York City Chinatown
- Ave. Duration
- 9h 30m
- Frequency
- Twice daily
- Estimated price
- $70–120
- Schedules at
- Flixbus USA
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide








