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How to get fromMount Pleasant to Chicagoby bus, plane, car, or train (Amtrak)

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There are 6 ways to get from Mount Pleasant to Chicago by bus, plane, car, or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, bus to Charleston International Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from Stuart Engals Blvd / Wando Crossing Shopping Center to Calhoun St / Jonathan Lucas Stbus bus
    2. Take the bus from Calhoun St / Jonathan Lucas St to Fuel Farm Rd / Dreamliner Drbus bus
    3. Fly from Charleston International Airport (CHS) to Chicago Midway International Airport (MDW)plane plane CHS - MDW
    5h 38m

  2. Fly Charleston International Airport to Chicago O'Hare International Airport

    cheapest
    1. Fly from Charleston International Airport (CHS) to Chicago O'Hare International Airport (ORD)plane plane CHS - ORD
    6h 7m
    $70–338

  3. Bus, drive

    1. Take the bus from Stuart Engals Blvd / Wando Crossing Center to S. Pinckney St / Society Rdbus bus
    2. Drive from S. Pinckney St / Society Rd to Myrtle Beach Bus Stationcar car
    3. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus
    27h 50m
    $176–358

  4. Train (Amtrak)

    1. Take the train from Charleston Amtrak Station to Petersburg Amtrak Stationtrain train Silver Meteor / ...
    2. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train Floridian
    29h 14m
    $440–887

  5. Drive 876.4 mi

    1. Drive from Mount Pleasant to Chicagocar car 876.4 mi
    16h 2m
    $160–231

  6. Drive to Hilton Head Airport, fly to Chicago O'Hare International Airport

    1. Drive from Mount Pleasant to Hilton Head Airport (HHH)car car
    2. Fly from Hilton Head Airport (HHH) to Chicago O'Hare International Airport (ORD)plane plane HHH - ORD
    5h 45m
    $87–363

Charleston International Airport (CHS) to Chicago Midway International Airport (MDW) flights

Calendar39Weekly Planes
Duration3h 38mAverage Duration
Ticket$77Cheapest Price
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Questions & Answers

Map of how to get from Mount Pleasant to Chicago.ExpandLaunch map view
  • Distance: 777.2 mi
  • Duration: 5h 38m

What companies run services between Mount Pleasant, SC, USA and Chicago, IL, USA?

You can take a vehicle from Mount Pleasant to Chicago Union Station via Charleston Amtrak Station and Petersburg Amtrak Station in around 29h 14m. Alternatively, American Airlines, United Airlines, and Delta fly from Charleston International Airport (CHS) to Chicago O'Hare International Airport (ORD) hourly.

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