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How to get fromMount Pleasant to Knoxvilleby plane, train, bus, or car

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There are 7 ways to get from Mount Pleasant to Knoxville by plane, train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Charleston International Airport (CHS) to Mcghee Tyson Airport (TYS)plane plane CHS - TYS
    6h 18m
    $148–623

  2. Drive 375.6 mi

    cheapest
    1. Drive from Mount Pleasant to Knoxvillecar car 375.6 mi
    6h 26m
    $69–99

  3. Train, bus

    1. Take the train from Charleston Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Palmetto / ...
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    28h 2m
    $408–690

  4. Bus, drive via Camden

    1. Take the bus from Stuart Engals Blvd / Wando Crossing Center to S. Pinckney St / Society Rdbus bus
    2. Drive from S. Pinckney St / Society Rd to Myrtle Beach Bus Stationcar car
    3. Take the bus from Myrtle Beach Bus Station to Camdenbus bus
    4. Take the bus from Camden to New York, NYbus bus
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    38h 24m
    $217–298

  5. Fly to Nashville, drive

    1. Fly from Charleston International Airport (CHS) to Nashville (BNA)plane plane CHS - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    7h 6m
    $383–1,153

  6. Train, bus via Farragut

    1. Take the train from Charleston Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Palmetto / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    30h 50m
    $419–739

  7. Bus, drive

    1. Take the bus from Stuart Engals Blvd / Wando Crossing Center to S. Pinckney St / Society Rdbus bus
    2. Drive from S. Pinckney St / Society Rd to Myrtle Beach Bus Stationcar car
    3. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    4. Take the bus from Fayetteville Bus Station to New York City Chinatownbus bus
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    42h 5m
    $260–403

Charleston International Airport (CHS) to Mcghee Tyson Airport (TYS) flights

Calendar104Weekly Planes
Duration4h 20mAverage Duration
Ticket$90Cheapest Price
See schedules

Questions & Answers

Map of how to get from Mount Pleasant to Knoxville.ExpandLaunch map view
  • Distance: 335.7 mi
  • Duration: 6h 18m

What companies run services between Mount Pleasant, SC, USA and Knoxville, TN, USA?

Delta, American Airlines, and two other airlines fly from Charleston International Airport (CHS) to Mcghee Tyson Airport (TYS) hourly.

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