Rome2Rio

How to get fromMount Pleasant to Louisvilleby bus, plane, car, or train

Find Transport to Louisville

See all options

There are 7 ways to get from Mount Pleasant to Louisville by bus, plane, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, fly to Louisville International Airport

    best
    1. Take the bus from Stuart Engals Blvd / Wando Crossing Shopping Center to Calhoun St / Jonathan Lucas Stbus bus
    2. Take the bus from Calhoun St / Jonathan Lucas St to Fuel Farm Rd / Dreamliner Drbus bus
    3. Fly from Charleston International Airport (CHS) to Louisville International Airport (SDF)plane plane CHS - SDF
    5h 49m

  2. Fly to Covington, bus

    cheapest
    1. Fly from Charleston International Airport (CHS) to Covington (CVG)plane plane CHS - CVG
    2. Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus bus
    8h 25m
    $94–1,050

  3. Bus, drive

    1. Take the bus from Stuart Engals Blvd / Wando Crossing Center to S. Pinckney St / Society Rdbus bus
    2. Drive from S. Pinckney St / Society Rd to Myrtle Beach Bus Stationcar car
    3. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Nashville Bus Stationbus bus
    5. Take the bus from Nashville to Louisville, KYbus bus
    22h 3m
    $131–248

  4. Train, bus (Amtrak)

    1. Take the train from Charleston Amtrak Station to Alexandriatrain train
    2. Take the train from Alexandria to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    31h 54m
    $432–892

  5. Drive 584.1 mi

    1. Drive from Mount Pleasant to Louisvillecar car 584.1 mi
    11h 20m
    $107–154

  6. Fly to Blue Grass Airport, drive

    1. Fly from Charleston International Airport (CHS) to Blue Grass Airport (LEX)plane plane CHS - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    7h 35m
    $136–722

  7. Bus, drive via Preston @ Vim

    1. Take the bus from Stuart Engals Blvd / Wando Crossing Center to S. Pinckney St / Society Rdbus bus
    2. Drive from S. Pinckney St / Society Rd to Myrtle Beach Bus Stationcar car
    3. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Nashville Bus Stationbus bus
    5. Take the bus from Tornado Bus Co - Nashville to La Tropicana - Louisville, KYbus bus
    22h 54m
    $154–353

Charleston International Airport (CHS) to Louisville International Airport (SDF) flights

Calendar59Weekly Planes
Duration3h 58mAverage Duration
Ticket$90Cheapest Price
See schedules

Questions & Answers

Map of how to get from Mount Pleasant to Louisville.ExpandLaunch map view
  • Distance: 513 mi
  • Duration: 5h 49m

What companies run services between Mount Pleasant, SC, USA and Louisville, KY, USA?

There is no direct connection from Mount Pleasant to Louisville. However, you can take the bus to Calhoun St / Jonathan Lucas St, take the bus to Fuel Farm Rd / Dreamliner Dr, walk to Charleston-Airport-CHS airport, fly to Louisville International Airport (SDF), walk to Louisville International Airport, then take the line 02 bus to 2nd @ York. Alternatively, you can take a bus from Stuart Engals Blvd / Wando Crossing Center to Louisville, KY via S. Pinckney St / Society Rd, Myrtle Beach Bus Station, Atlanta Bus Station, and Nashville in around 22h 3m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound