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How to get fromMount Pleasant to St. Louisby bus, plane, or car

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There are 5 ways to get from Mount Pleasant to St. Louis by bus, plane, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, bus to Charleston International Airport, fly

    best
    1. Take the bus from Stuart Engals Blvd / Wando Crossing Shopping Center to Calhoun St / Jonathan Lucas Stbus bus
    2. Take the bus from Calhoun St / Jonathan Lucas St to Fuel Farm Rd / Dreamliner Drbus bus
    3. Fly from Charleston International Airport (CHS) to Lambert–St. Louis International Airport (STL)plane plane CHS - STL
    5h 34m

  2. Drive to Hilton Head Airport, fly

    cheapest
    1. Drive from Mount Pleasant to Hilton Head Airport (HHH)car car
    2. Fly from Hilton Head Airport (HHH) to Lambert–St. Louis International Airport (STL)plane plane HHH - STL
    8h 7m
    $123–581

  3. Bus, drive via Carbondale

    1. Take the bus from Stuart Engals Blvd / Wando Crossing Center to S. Pinckney St / Society Rdbus bus
    2. Drive from S. Pinckney St / Society Rd to Myrtle Beach Bus Stationcar car
    3. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Carbondale Intermodal Stationbus bus
    5. Take the bus from Carbondale to St. Louisbus bus
    24h 50m
    $156–308

  4. Drive 843.9 mi

    1. Drive from Mount Pleasant to St. Louiscar car 843.9 mi
    14h 47m
    $154–223

  5. Bus, drive

    1. Take the bus from Stuart Engals Blvd / Wando Crossing Center to S. Pinckney St / Society Rdbus bus
    2. Drive from S. Pinckney St / Society Rd to Myrtle Beach Bus Stationcar car
    3. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    25h 9m
    $151–298

Charleston International Airport (CHS) to Lambert–St. Louis International Airport (STL) flights

Calendar46Weekly Planes
Duration3h 43mAverage Duration
Ticket$108Cheapest Price
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Questions & Answers

Map of how to get from Mount Pleasant to St. Louis.ExpandLaunch map view
  • Distance: 739.6 mi
  • Duration: 5h 34m

What companies run services between Mount Pleasant, SC, USA and St. Louis, MO, USA?

There is no direct connection from Mount Pleasant to St. Louis. However, you can take the bus to Calhoun St / Jonathan Lucas St, take the bus to Fuel Farm Rd / Dreamliner Dr, walk to Charleston-Airport-CHS airport, fly to Lambert–St. Louis International Airport (STL), walk to LAMBERT AIRPORT TERMINAL #1 station, then take the train to CIVIC CENTER station. Alternatively, you can take a bus from Stuart Engals Blvd / Wando Crossing Center to St. Louis via S. Pinckney St / Society Rd, Myrtle Beach Bus Station, Atlanta Bus Station, and Carbondale in around 24h 50m.

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