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How to get fromMount Prospect to Mayo Clinicby train, plane, bus, or car

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There are 6 ways to get from Mount Prospect to Mayo Clinic by train, plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Chicago O'Hare International Airport, fly to Rochester

    best
    1. Take the train from Mt. Prospect to Irving Parktrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    4h 41m
    $65–321

  2. Drive 327.1 mi

    cheapest
    1. Drive from Mount Prospect to Mayo Cliniccar car 327.1 mi
    5h 25m
    $60–87

  3. Bus

    1. Take the bus from Multi-Modal/Rental Car Facility to 250 N. Lake St - Madison UW Campusbus bus Van Galder
    2. Take the bus from Madison to Rochesterbus bus Jefferson 966 / ...
    9h 21m
    $76–130

  4. Fly Chicago O'Hare International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Minneapolis–Saint Paul International Airport (MSP)plane plane ORD - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 16m
    $278–462

  5. Fly Chicago Midway International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Minneapolis–Saint Paul International Airport (MSP)plane plane MDW - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 7m
    $133–542

  6. Train, bus

    1. Take the train from Chicago Union Station to Milwaukeetrain train Hiawatha Service / ...
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson 966 / ...
    10h 7m
    $104–168

Chicago O'Hare International Airport (ORD) to Rochester (RST) flights

Calendar35Weekly Planes
Duration1h 53mAverage Duration
Ticket$45Cheapest Price
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Questions & Answers

Map of how to get from Mount Prospect to Mayo Clinic.ExpandLaunch map view
  • Distance: 300.2 mi
  • Duration: 4h 41m

What companies run services between Mount Prospect, IL, USA and Mayo Clinic, MN, USA?

You can take a bus from State St & Cornell Ave to Mayo Clinic via River Rd & Miner St, Des Plaines Metra Station, Multi-Modal/Rental Car Facility, Madison, and Rochester in around 9h 21m.

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