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How to get fromMount Prospect to Mayo Clinicby train, plane, bus, or car

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There are 7 ways to get from Mount Prospect to Mayo Clinic by train, plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Chicago O'Hare International Airport, fly to Rochester

    best
    1. Take the train from Mt. Prospect to Irving Parktrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    4h 43m
    $47–330

  2. Bus

    1. Take the bus from Multi-Modal/Rental Car Facility to 250 N. Lake St - Madison UW Campusbus bus Van Galder
    2. Take the bus from Madison to Rochesterbus bus Jefferson Lines 966
    9h 41m
    $76–130

  3. Train, bus via Saint Paul

    1. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train Borealis / ...
    2. Take the bus from St. Paul to Rochesterbus bus Jefferson Lines 965
    11h 54m
    $135–288

  4. Drive  327.1 mi

    1. Drive from Mount Prospect to Mayo Cliniccar car 327.1 mi
    5h 25m
    $60–87

  5. Fly Chicago O'Hare International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Minneapolis–Saint Paul International Airport (MSP)plane plane ORD - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 22m
    $288–762

  6. Fly Chicago Midway International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Minneapolis–Saint Paul International Airport (MSP)plane plane MDW - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 7m
    $133–552

  7. Train, bus

    1. Take the train from Chicago Union Station to Milwaukeetrain train Hiawatha Service / ...
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson Lines 966
    10h 7m
    $99–158

Mount Prospect to Mayo Clinic by bus and foot

Calendar7Weekly Services
Duration9h 41mAverage Duration
Ticket$76Cheapest Price
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Questions & Answers

Map of how to get from Mount Prospect to Mayo Clinic.ExpandLaunch map view
  • Distance: 300.2 mi
  • Duration: 4h 43m

What companies run services between Mount Prospect, IL, USA and Mayo Clinic, MN, USA?

You can take a bus from State St & Cornell Ave to Mayo Clinic via River Rd & Miner St, Des Plaines Metra Station, Multi-Modal/Rental Car Facility, 250 N. Lake St - Madison UW Campus, Madison, and Rochester in around 9h 41m.

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