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How to get fromMount Prospect to St. Louisby train (Amtrak), bus (Flixbus), car, train, plane, subway, or bus

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There are 6 ways to get from Mount Prospect to St. Louis by train (Amtrak), bus (Flixbus), car, train, plane, subway, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    6h 36m
    $82–178

  2. Drive  299 mi

    cheapest
    1. Drive from Mount Prospect to St. Louiscar car 299 mi
    5h 7m
    $55–79

  3. Bus

    1. Take the bus from Woodfield Mall to Illinois Terminalbus bus Chicago to Champaign via shopping SB / ...
    2. Take the bus from Champaign Intermodal Trans Ctr to St Louis Bus Stationbus bus FlixBus N2521 / ...
    9h 9m
    $72–108

  4. Train to Chicago O'Hare International Airport, fly

    1. Take the train from Mt. Prospect to Irving Parktrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    3h 58m
    $279–713

  5. Train, subway to Chicago Midway International Airport, fly

    1. Take the train from Mt. Prospect to Chicago OTCtrain train
    2. Take the subway from Clark/Lake to Midwaysubway subway
    3. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    4h 37m
    $79–513

  6. Bus to General Mitchell International Airport, fly

    1. Take the bus from Multi-Modal/Rental Car Facility to Mitchell Airportbus bus
    2. Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane plane MKE - STL
    5h 39m
    $522–898

Mount Prospect to St. Louis by train and bus (Amtrak)

Calendar38Weekly Services
Duration6h 36mAverage Duration
Ticket$82Cheapest Price
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Questions & Answers

Map of how to get from Mount Prospect to St. Louis.ExpandLaunch map view
  • Distance: 301.2 mi
  • Duration: 6h 36m

What companies run services between Mount Prospect, IL, USA and St. Louis, MO, USA?

Amtrak operates a train from Chicago Union Station to St. Louis 5 times a day. Tickets cost $75–170 and the journey takes 4h 46m. Alternatively, you can take a bus from Golf Rd & Wa Pella Ave/Hunt Club Dr to St Louis Bus Station via Northwest Transportation Center, Woodfield Mall, Illinois Terminal, and Champaign Intermodal Trans Ctr in around 9h 9m.

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