There are 6 ways to get from Murphysboro to Chicago by plane, train (Amtrak), bus (Flixbus, Amtrak), car, or taxi
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Williamson County Regional Airport
best- Fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD)plane MWA - ORD
2h 50m$131–273Drive to Barkley Regional Airport, fly
cheapest- Drive from Murphysboro to Barkley Regional Airport (PAH)car
- Fly from Barkley Regional Airport (PAH) to Chicago O'Hare International Airport (ORD)plane PAH - ORD
3h 43m$51–285Train (Amtrak)
- Take the train from Carbondale to Chicago Union Stationtrain Saluki / ...
5h 41m$189–293Bus
- Take the bus from Carbondale Intermodal Station to St Louis Bus Stationbus FlixBus N2521
- Take the bus from St Louis Bus Station to Chicago Bus Stationbus FlixBus N2521 / ...
9h 11m$84–121Drive 331.9 mi
- Drive from Murphysboro to Chicagocar 331.9 mi
5h 44m$61–88Taxi to Cape Girardeau Municipal Airport, fly
- Take the taxi from Murphysboro to Cape Girardeau Municipal Airport (CGI)taxi
- Fly from Cape Girardeau Municipal Airport (CGI) to Chicago O'Hare International Airport (ORD)plane CGI - ORD
3h 56m$214–473
Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD) flights
Comparing Your Travel Options
The cheapest way to get from Murphysboro to Chicago is to drive which costs $60 - $90 and takes 5h 44m.
The fastest way to get from Murphysboro to Chicago is to fly which takes 2h 50m and costs $130 - $280.
No, there is no direct bus from Murphysboro station to Chicago station. However, there are services departing from Carbondale Intermodal Station and arriving at Chicago Bus Station via St Louis Bus Station. The journey, including transfers, takes approximately 9h 11m.
No, there is no direct train from Murphysboro to Chicago station. However, there are services departing from Carbondale and arriving at Chicago Union Station via . The journey, including transfers, takes approximately 5h 41m.
The distance between Murphysboro and Chicago is 337 miles. The road distance is 333.9 miles.
The best way to get from Murphysboro to Chicago without a car is to train which takes 5h 41m and costs $180 - $300.
It takes approximately 2h 50m to get from Murphysboro to Chicago, including transfers.
Murphysboro to Chicago bus services, operated by Flixbus USA, depart from Carbondale Intermodal Station.
Murphysboro to Chicago train services, operated by Amtrak, depart from Carbondale station.
The best way to get from Murphysboro to Chicago is to fly which takes 2h 50m and costs $130 - $280. Alternatively, you can train, which costs $180 - $300 and takes 5h 41m, you could also bus, which costs $80 - $130 and takes 9h 11m.
What companies run services between Murphysboro, IL, USA and Chicago, IL, USA?
American Airlines flies from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD) 3 times a day. Alternatively, Amtrak operates a train from Carbondale to Chicago Union Station 3 times a day. Tickets cost $170–270 and the journey takes 5h 30m.
- Website
- aa.com
Flights from Williamson County Regional Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- $35–250
- Website
- united.com
Flights from Barkley Regional Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 29m
- When
- Every day
- Estimated price
- $35–260
- Website
- contouraviation.com
Flights from Cape Girardeau Municipal Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 55m
- When
- Every day
- Estimated price
- $95–330
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Carbondale to Chicago Union Station
- Ave. Duration
- 5h 30m
- Frequency
- 3 times a day
- Estimated price
- $170–270
- Website
- Amtrak
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Carbondale Intermodal Station to St Louis Bus Station
- Ave. Duration
- 1h 55m
- Frequency
- 5 times a week
- Estimated price
- $15–23
- Schedules at
- Flixbus USA
Bus from St Louis Bus Station to Chicago Bus Station
- Ave. Duration
- 6h 5m
- Frequency
- Twice daily
- Estimated price
- $50–75
- Schedules at
- Flixbus USA
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from Carbondale Intermodal Station to St Louis Bus Station
- Ave. Duration
- 2h
- Frequency
- Once daily
- Website
- Amtrak
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Booking & Getting There
Murphysboro to Chicago bus services, operated by Flixbus USA, arrive at St Louis Bus Station.
Murphysboro to Chicago train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Murphysboro to Chicago is 334 miles. It takes approximately 5h 44m to drive from Murphysboro to Chicago.
Book your Murphysboro to Chicago train tickets online with Omio.
Book your Murphysboro to Chicago bus tickets online with Omio.
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