There are 6 ways to get from Murphysboro to Chicago by plane, train (Amtrak), bus (Amtrak, Flixbus), car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Williamson County Regional Airport to Chicago O'Hare International Airport
best- Fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD)plane MWA - ORD
2h 56m$131–273Drive to Barkley Regional Airport, fly to Chicago O'Hare International Airport
cheapest- Drive from Murphysboro to Barkley Regional Airport (PAH)car
- Fly from Barkley Regional Airport (PAH) to Chicago O'Hare International Airport (ORD)plane PAH - ORD
3h 41m$56–295Train (Amtrak)
- Take the train from Carbondale to Chicago Union Stationtrain Saluki / ...
5h 41m$99–213Bus
- Take the bus from Carbondale to St. Louisbus Amtrak Thruway Connecting Service
- Take the bus from St Louis Bus Station to Chicago Bus Stationbus FlixBus N2521 / ...
9h 16m$72–143Drive 331.9 mi
- Drive from Murphysboro to Chicagocar 331.9 mi
5h 44m$61–88Bus to Lambert–St. Louis International Airport, fly to Chicago Midway International Airport
- Take the bus from Carbondale to St. Louisbus
- Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)plane STL - MDW
5h 41m$87–426
Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD) flights
Questions & Answers
The cheapest way to get from Murphysboro to Chicago is to drive which costs $60 - $90 and takes 5h 44m.
The fastest way to get from Murphysboro to Chicago is to fly which takes 2h 56m and costs $130 - $280.
No, there is no direct bus from Murphysboro to Chicago station. However, there are services departing from Carbondale and arriving at Chicago Bus Station via St Louis Bus Station. The journey, including transfers, takes approximately 9h 16m.
No, there is no direct train from Murphysboro to Chicago station. However, there are services departing from Carbondale and arriving at Chicago Union Station via . The journey, including transfers, takes approximately 5h 41m.
The distance between Murphysboro and Chicago is 337 miles. The road distance is 333.9 miles.
The best way to get from Murphysboro to Chicago without a car is to train which takes 5h 41m and costs $95 - $220.
It takes approximately 2h 56m to get from Murphysboro to Chicago, including transfers.
Murphysboro to Chicago bus services, operated by Amtrak, depart from Carbondale station.
Murphysboro to Chicago train services, operated by Amtrak, depart from Carbondale station.
The best way to get from Murphysboro to Chicago is to fly which takes 2h 56m and costs $130 - $280. Alternatively, you can train, which costs $95 - $220 and takes 5h 41m, you could also bus, which costs $70 - $150 and takes 9h 16m.
What companies run services between Murphysboro, IL, USA and Chicago, IL, USA?
American Airlines flies from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD) twice daily. Alternatively, Amtrak operates a train from Carbondale to Chicago Union Station 3 times a day. Tickets cost $80–190 and the journey takes 5h 30m.
- Website
- southwest.com
Flights from Lambert–St. Louis International Airport to Chicago Midway International Airport
- Ave. Duration
- 1h 5m
- When
- Every day
- Estimated price
- $50–350
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Carbondale to Chicago Union Station
- Ave. Duration
- 5h 30m
- Frequency
- 3 times a day
- Estimated price
- $80–190
- Website
- Amtrak
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from Carbondale to St. Louis
- Ave. Duration
- 2h
- Frequency
- Once daily
- Estimated price
- $29–45
- Website
- Amtrak
Bus from Carbondale to St. Louis
- Ave. Duration
- 2h
- Frequency
- Once daily
- Estimated price
- $29–45
- Website
- Amtrak
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More Questions & Answers
Murphysboro to Chicago bus services, operated by Amtrak, arrive at St. Louis station.
Murphysboro to Chicago train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Murphysboro to Chicago is 334 miles. It takes approximately 5h 44m to drive from Murphysboro to Chicago.
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Book your Murphysboro to Chicago bus tickets online with Omio.
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