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How to get fromMurphysboro to Louisvilleby bus (Flixbus, Amtrak), car, plane, train, bus, or bus (Flixbus)

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There are 7 ways to get from Murphysboro to Louisville by bus (Flixbus, Amtrak), car, plane, train, bus, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Carbondale Intermodal Station to Nashville Bus Stationbus bus FlixBus N2521
    2. Take the bus from Nashville to Louisville, KYbus bus Nashville
    8h 46m
    $79–123

  2. Drive  222.4 mi

    cheapest
    1. Drive from Murphysboro to Louisvillecar car 222.4 mi
    4h 15m
    $41–59

  3. Fly from Williamson County Regional Airport

    1. Fly from Williamson County Regional Airport (MWA) to Louisville International Airport (SDF)plane plane MWA - SDF
    6h 39m
    $180–861

  4. Train, bus

    1. Take the train from Carbondale to Champaign-Urbanatrain train
    2. Take the bus from Champaign Intermodal Trans Ctr to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    8h 56m
    $162–263

  5. Bus via Preston @ Vim

    1. Take the bus from Carbondale Intermodal Station to Nashville Bus Stationbus bus FlixBus N2521
    2. Take the bus from Tornado Bus Co - Nashville to La Tropicana - Louisville, KYbus bus Memphis
    9h 37m
    $87–138

  6. Drive to Barkley Regional Airport, fly

    1. Drive from Murphysboro to Barkley Regional Airport (PAH)car car
    2. Fly from Barkley Regional Airport (PAH) to Louisville International Airport (SDF)plane plane PAH - SDF
    9h 19m
    $135–723

  7. Bus to Lambert–St. Louis International Airport, fly

    1. Take the bus from Carbondale to St. Louisbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF)plane plane STL - SDF
    8h 11m
    $148–752

Williamson County Regional Airport (MWA) to Louisville International Airport (SDF) flights

Calendar24Weekly Planes
Duration7h 32mAverage Duration
Ticket$137Cheapest Price
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Comparing Your Travel Options

Map of how to get from Murphysboro to Louisville.ExpandLaunch map view
  • Distance: 388.5 mi
  • Duration: 8h 46m

What companies run services between Murphysboro, IL, USA and Louisville, KY, USA?

You can take a vehicle from Murphysboro to Louisville, KY via Carbondale Intermodal Station and Nashville in around 8h 46m. Alternatively, American Airlines flies from Williamson County Regional Airport (MWA) to Louisville International Airport (SDF) 3 times a day.

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