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How to get fromMurphysboro to Louisvilleby bus (Flixbus, Greyhound), car, plane, train, or bus

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There are 6 ways to get from Murphysboro to Louisville by bus (Flixbus, Greyhound), car, plane, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Carbondale Intermodal Station to Clarksville Park & Ridebus bus FlixBus N2521
    2. Take the bus from Clarksville Park & Ride to Louisville Bus Stationbus bus Greyhound US0112
    7h 46m
    $71–108

  2. Drive  222.4 mi

    cheapest
    1. Drive from Murphysboro to Louisvillecar car 222.4 mi
    4h 15m
    $41–59

  3. Fly from Williamson County Regional Airport

    1. Fly from Williamson County Regional Airport (MWA) to Louisville International Airport (SDF)plane plane MWA - SDF
    7h 27m
    $180–811

  4. Train, bus

    1. Take the train from Carbondale to Champaign-Urbanatrain train
    2. Take the bus from Champaign Intermodal Trans Ctr to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus
    8h 56m
    $104–208

  5. Drive to Barkley Regional Airport, fly

    1. Drive from Murphysboro to Barkley Regional Airport (PAH)car car
    2. Fly from Barkley Regional Airport (PAH) to Louisville International Airport (SDF)plane plane PAH - SDF
    9h 4m
    $125–673

  6. Bus to Lambert–St. Louis International Airport, fly

    1. Take the bus from Carbondale to St. Louisbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF)plane plane STL - SDF
    8h 6m
    $147–769

Williamson County Regional Airport (MWA) to Louisville International Airport (SDF) flights

Calendar28Weekly Planes
Duration8h 28mAverage Duration
Ticket$132Cheapest Price
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Questions & Answers

Map of how to get from Murphysboro to Louisville.ExpandLaunch map view
  • Distance: 349.8 mi
  • Duration: 7h 46m

What companies run services between Murphysboro, IL, USA and Louisville, KY, USA?

You can take a vehicle from Murphysboro to Louisville Bus Station via Carbondale Intermodal Station and Clarksville Park & Ride in around 7h 46m. Alternatively, American Airlines flies from Williamson County Regional Airport (MWA) to Louisville International Airport (SDF) 4 times a day.

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