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How to get fromMurphysboro to Louisvilleby taxi, bus, car, plane, or bus (Flixbus, Amtrak)

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There are 6 ways to get from Murphysboro to Louisville by taxi, bus, car, plane, or bus (Flixbus, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi, bus

    best
    1. Take the taxi from Murphysboro to Mount Vernontaxi taxi
    2. Take the bus from Mount Vernon to Evansville Bus Stationbus bus
    3. Take the bus from Evansville, IN to Louisville, KYbus bus
    6h 2m
    $177–233

  2. Drive 222.4 mi

    cheapest
    1. Drive from Murphysboro to Louisvillecar car 222.4 mi
    4h 15m
    $41–59

  3. Fly from Williamson County Regional Airport

    1. Fly from Williamson County Regional Airport (MWA) to Louisville International Airport (SDF)plane plane MWA - SDF
    7h 58m
    $150–661

  4. Bus

    1. Take the bus from Carbondale Intermodal Station to Nashville Bus Stationbus bus FlixBus N2521
    2. Take the bus from Nashville to Louisville, KYbus bus
    8h 36m
    $79–128

  5. Drive to Barkley Regional Airport, fly

    1. Drive from Murphysboro to Barkley Regional Airport (PAH)car car
    2. Fly from Barkley Regional Airport (PAH) to Louisville International Airport (SDF)plane plane PAH - SDF
    9h 49m
    $110–573

  6. Bus to Lambert–St. Louis International Airport, fly

    1. Take the bus from Carbondale to St. Louisbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF)plane plane STL - SDF
    8h 26m
    $138–679

Williamson County Regional Airport (MWA) to Louisville International Airport (SDF) flights

Calendar11Weekly Planes
Duration6h 35mAverage Duration
Ticket$108Cheapest Price
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Questions & Answers

Map of how to get from Murphysboro to Louisville.ExpandLaunch map view
  • Distance: 264.9 mi
  • Duration: 6h 2m

What companies run services between Murphysboro, IL, USA and Louisville, KY, USA?

American Airlines, Corporate Flight Management Inc, and United Airlines fly from Williamson County Regional Airport (MWA) to Louisville International Airport (SDF) twice daily. Alternatively, you can take a vehicle from Murphysboro to Louisville, KY via Carbondale Intermodal Station and Nashville in around 8h 36m.

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