There are 7 ways to get from Murphysboro to Milwaukee by bus, train (Amtrak), car, plane, or bus (Amtrak, Flixbus, Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Marathon Gas Station - Marion to Water & Chicago - Circle Kbus Milwaukee
8h 4m$136–171Drive 419.7 mi
cheapest- Drive from Murphysboro to Milwaukeecar 419.7 mi
7h 18m$77–111Train (Amtrak)
- Take the train from Carbondale to Chicago Union Stationtrain Saluki / ...
- Take the train from Chicago Union Station to Milwaukeetrain Hiawatha Service / ...
8h 10m$114–253Fly Williamson County Regional Airport to General Mitchell International Airport
- Fly from Williamson County Regional Airport (MWA) to General Mitchell International Airport (MKE)plane MWA - MKE
5h 49m$137–661Bus via Chicago
- Take the bus from Carbondale to St. Louisbus
- Take the bus from St Louis Bus Station to Chicago Bus Stationbus
- Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus
11h 56m$91–155Fly Williamson County Regional Airport to Chicago O'Hare International Airport, bus
- Fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD)plane MWA - ORD
- Take the bus from Chicago to Milwaukee Intermodal Stationbus
4h 42m$143–293Bus to Lambert–St. Louis International Airport, fly to General Mitchell International Airport
- Take the bus from Carbondale to St. Louisbus
- Fly from Lambert–St. Louis International Airport (STL) to General Mitchell International Airport (MKE)plane STL - MKE
5h 41m$519–914
Williamson County Regional Airport (MWA) to General Mitchell International Airport (MKE) flights
Comparing Your Travel Options
The cheapest way to get from Murphysboro to Milwaukee is to drive which costs $75 - $120 and takes 7h 18m.
The fastest way to get from Murphysboro to Milwaukee is to fly and bus which takes 4h 42m and costs $140 - $300.
No, there is no direct bus from Murphysboro station to Milwaukee. However, there are services departing from Marathon Gas Station - Marion and arriving at Water & Chicago - Circle K via . The journey, including transfers, takes approximately 8h 4m.
No, there is no direct train from Murphysboro to Milwaukee. However, there are services departing from Carbondale and arriving at Milwaukee via Chicago Union Station. The journey, including transfers, takes approximately 8h 10m.
The distance between Murphysboro and Milwaukee is 432 miles. The road distance is 422.1 miles.
The best way to get from Murphysboro to Milwaukee without a car is to bus which takes 8h 4m and costs $130 - $180.
It takes approximately 8h 4m to get from Murphysboro to Milwaukee, including transfers.
Murphysboro to Milwaukee bus services, operated by Amtrak, depart from Carbondale station.
Murphysboro to Milwaukee train services, operated by Amtrak, depart from Carbondale station.
The best way to get from Murphysboro to Milwaukee is to bus which takes 8h 4m and costs $130 - $180. Alternatively, you can train, which costs $110 - $260 and takes 8h 10m, you could also fly, which costs $130 - $700 and takes 5h 49m.
What companies run services between Murphysboro, IL, USA and Milwaukee, WI, USA?
Tornado Bus Company operates a bus from Marathon Gas Station - Marion to Water & Chicago - Circle K once daily. Tickets cost $85–110 and the journey takes 7h 35m. Alternatively, you can take a vehicle from Murphysboro to Milwaukee via Carbondale and Chicago Union Station in around 8h 10m.
- Website
- southwest.com
Flights from Lambert–St. Louis International Airport to General Mitchell International Airport
- Ave. Duration
- 1h 12m
- When
- Every day
- Estimated price
- $80–550
Flights from Lambert–St. Louis International Airport to General Mitchell International Airport via Chicago Midway
- Ave. Duration
- 2h 50m
- When
- Tuesday and Wednesday
- Estimated price
- $80–550
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Carbondale to Chicago Union Station
- Ave. Duration
- 5h 30m
- Frequency
- 3 times a day
- Estimated price
- $75–180
- Website
- Amtrak
Train from Chicago Union Station to Milwaukee
- Ave. Duration
- 1h 29m
- Frequency
- Every 4 hours
- Estimated price
- $20–50
- Website
- Amtrak
- Phone
- +1 888 358 6762
- [email protected]
- Website
- Tornado Bus Company
Bus from Marathon Gas Station - Marion to Water & Chicago - Circle K
- Ave. Duration
- 7h 35m
- Frequency
- Once daily
- Estimated price
- $85–110
- Schedules at
- Tornado Bus Company
- Adult
- $85–110
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Booking & Getting There
Murphysboro to Milwaukee bus services, operated by Amtrak, arrive at St. Louis station.
Murphysboro to Milwaukee train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Murphysboro to Milwaukee is 422 miles. It takes approximately 7h 18m to drive from Murphysboro to Milwaukee.
Book your Murphysboro to Milwaukee train tickets online with Omio.
Book your Murphysboro to Milwaukee bus tickets online with Omio.
There are 314+ hotels available in Milwaukee.