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How to get fromMurrells Inlet to Buffaloby plane, bus (Greyhound), car, train, bus, or bus (Greyhound, Flixbus)

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There are 7 ways to get from Murrells Inlet to Buffalo by plane, bus (Greyhound), car, train, bus, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF)plane plane MYR - BUF
    5h 11m
    $136–576

  2. Bus

    1. Take the bus from Myrtle Beach Bus Station to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte Bus Station to Charleston, WVbus bus
    4. Take the bus from Charleston, WV to Cleveland, OHbus bus
    5. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    23h 56m
    $154–317

  3. Drive, train (Amtrak)

    1. Drive from Murrells Inlet to Kingstree Stationcar car
    2. Take the train from Kingstree Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    24h 22m
    $301–677

  4. Drive 770.3 mi

    1. Drive from Murrells Inlet to Buffalocar car 770.3 mi
    15h 52m
    $141–204

  5. Fly to Rochester, bus

    1. Fly from Myrtle Beach (MYR) to Rochester (ROC)plane plane MYR - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    5h 5m
    $259–790

  6. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the train from Fayetteville Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    30h 49m
    $343–751

  7. Bus via Washington

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the bus from Fayetteville Bus Station to Washington Union Stationbus bus
    3. Take the bus from Washington Union Station to Ithacabus bus
    4. Take the bus from Ithaca to Buffalobus bus
    32h 26m
    $231–396

Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF) flights

Calendar75Weekly Planes
Duration5h 1mAverage Duration
Ticket$93Cheapest Price
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Questions & Answers

Map of how to get from Murrells Inlet to Buffalo.ExpandLaunch map view
  • Distance: 662.1 mi
  • Duration: 5h 11m

What companies run services between Murrells Inlet, SC, USA and Buffalo, NY, USA?

Southwest Airlines, American Airlines, and Delta fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF) every 2 hours. Alternatively, you can take a vehicle from Murrells Inlet to Buffalo, NY via Myrtle Beach Bus Station, Camden, Charlotte Bus Station, Charleston, WV, and Cleveland, OH in around 23h 56m.

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