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How to get fromMurrells Inlet to Great Smoky Mountainsby plane, car, bus, train, or shuttle

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There are 8 ways to get from Murrells Inlet to Great Smoky Mountains by plane, car, bus, train, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Asheville Regional Airport, drive

    best
    1. Fly from Myrtle Beach (MYR) to Asheville Regional Airport (AVL)plane plane MYR - AVL
    2. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    5h 27m
    $95–340

  2. Drive  369.4 mi

    cheapest
    1. Drive from Murrells Inlet to Great Smoky Mountainscar car 369.4 mi
    7h 41m
    $68–98

  3. Bus, drive (Greyhound)

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Take the bus from Wilmington Cape Fear Public Transit to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Asheville, NCbus bus
    4. Drive from Asheville, NC to Great Smoky Mountainscar car
    14h 5m
    $129–220

  4. Fly to Mcghee Tyson Airport, drive

    1. Fly from Myrtle Beach (MYR) to Mcghee Tyson Airport (TYS)plane plane MYR - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    5h 27m
    $141–664

  5. Bus, drive via Camden

    1. Take the bus from Myrtle Beach Bus Station to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    4. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    5. Drive from Asheville, NC to Great Smoky Mountainscar car
    14h 15m
    $116–221

  6. Drive, train, bus

    1. Drive from Murrells Inlet to Kingstree Stationcar car
    2. Take the train from Kingstree Station to Selma Stationtrain train
    3. Take the train from Selma Station to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    5. Drive from Asheville, NC to Great Smoky Mountainscar car
    14h 25m
    $125–257

  7. Bus, drive #2 (Greyhound)

    1. Take the bus from Myrtle Beach Bus Station to Raleigh Bus Stationbus bus
    2. Take the bus from Raleigh Bus Station to Asheville, NCbus bus
    3. Drive from Asheville, NC to Great Smoky Mountainscar car
    18h 45m
    $166–291

  8. Bus, shuttle, drive

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the bus from Fayetteville to Winston-Salembus bus
    3. Take the bus from Winston-Salem to Boonebus bus
    4. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    6. Drive from Hot Springs to Great Smoky Mountainscar car
    23h 3m
    $378–471

Myrtle Beach (MYR) to Asheville Regional Airport (AVL) flights

Calendar58Weekly Planes
Duration4h 11mAverage Duration
Ticket$39Cheapest Price
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Questions & Answers

Map of how to get from Murrells Inlet to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 332.5 mi
  • Duration: 5h 27m

What companies run services between Murrells Inlet, SC, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Murrells Inlet to Great Smoky Mountains. However, you can take the taxi to Myrtle Beach (MYR) airport, fly to Asheville Regional Airport (AVL), then drive to Great Smoky Mountains. Alternatively, you can take a vehicle from Murrells Inlet to Great Smoky Mountains via Myrtle Beach Bus Station, Wilmington Cape Fear Public Transit, Raleigh Bus Station, and Asheville, NC in around 14h 5m.

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