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How to get fromMurrells Inlet to Great Smoky Mountainsby plane, car, bus, or train

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There are 8 ways to get from Murrells Inlet to Great Smoky Mountains by plane, car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport, drive

    best
    1. Fly from Myrtle Beach (MYR) to Mcghee Tyson Airport (TYS)plane plane MYR - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    5h 38m
    $131–614

  2. Drive 369.4 mi

    cheapest
    1. Drive from Murrells Inlet to Great Smoky Mountainscar car 369.4 mi
    7h 41m
    $68–98

  3. Bus, drive (Greyhound)

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Take the bus from Wilmington Cape Fear Public Transit to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Asheville, NCbus bus
    4. Drive from Asheville, NC to Great Smoky Mountainscar car
    14h 5m
    $130–220

  4. Fly to Asheville Regional Airport, drive

    1. Fly from Myrtle Beach (MYR) to Asheville Regional Airport (AVL)plane plane MYR - AVL
    2. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    5h 35m
    $95–340

  5. Fly to Hartsfield-Jackson Atlanta International Airport, drive

    1. Fly from Myrtle Beach (MYR) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane MYR - ATL
    2. Drive from Atlanta-Airport-ATL to Great Smoky Mountainscar car
    5h 50m
    $306–853

  6. Bus, drive via Camden

    1. Take the bus from Myrtle Beach Bus Station to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    4. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    5. Drive from Asheville, NC to Great Smoky Mountainscar car
    14h 15m
    $117–220

  7. Drive, train, bus

    1. Drive from Murrells Inlet to Kingstree Stationcar car
    2. Take the train from Kingstree Station to Selma Stationtrain train
    3. Take the train from Selma Station to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    5. Drive from Asheville, NC to Great Smoky Mountainscar car
    14h 25m
    $142–287

  8. Bus, drive #2 (Greyhound)

    1. Take the bus from Myrtle Beach Bus Station to Raleigh Bus Stationbus bus
    2. Take the bus from Raleigh Bus Station to Asheville, NCbus bus
    3. Drive from Asheville, NC to Great Smoky Mountainscar car
    18h 45m
    $166–291

Myrtle Beach (MYR) to Mcghee Tyson Airport (TYS) flights

Calendar67Weekly Planes
Duration4h 39mAverage Duration
Ticket$84Cheapest Price
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Questions & Answers

Map of how to get from Murrells Inlet to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 395.2 mi
  • Duration: 5h 38m

What companies run services between Murrells Inlet, SC, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Murrells Inlet to Great Smoky Mountains. However, you can take the taxi to Myrtle Beach (MYR) airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take a vehicle from Murrells Inlet to Great Smoky Mountains via Myrtle Beach Bus Station, Wilmington Cape Fear Public Transit, Raleigh Bus Station, and Asheville, NC in around 14h 5m.

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