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How to get fromMurrells Inlet to Key Westby plane, car, train, bus, bus (Greyhound, Flixbus), or shuttle

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There are 7 ways to get from Murrells Inlet to Key West by plane, car, train, bus, bus (Greyhound, Flixbus), or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Myrtle Beach

    best
    1. Fly from Myrtle Beach (MYR) to Key West International Airport (EYW)plane plane MYR - EYW
    4h 46m
    $402–661

  2. Drive to Florence Regional Airport, fly

    cheapest
    1. Drive from Murrells Inlet to Florence Regional Airport (FLO)car car
    2. Fly from Florence Regional Airport (FLO) to Key West International Airport (EYW)plane plane FLO - EYW
    8h 9m
    $90–373

  3. Drive, train, bus

    1. Drive from Murrells Inlet to Kingstree Stationcar car
    2. Take the train from Kingstree Station to Hollywood Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    24h 3m
    $265–527

  4. Bus

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Take the bus from Wilmington Cape Fear Public Transit to Fayetteville Bus Stationbus bus
    3. Take the bus from Fayetteville Bus Station to Ft Lauderdale Broward Park & Ridebus bus
    4. Take the bus from Ft Lauderdale Broward Park & Ride to Miami Airport Stationbus bus
    5. Take the bus from Miami Airport Station to Big Pine Keybus bus
    6. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    29h 48m
    $207–350

  5. Drive 821 mi

    1. Drive from Murrells Inlet to Key Westcar car 821 mi
    15h 1m
    $150–217

  6. Bus to Wilmington International Airport, fly

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Fly from Wilmington International Airport (ILM) to Key West International Airport (EYW)plane plane ILM - EYW
    7h 10m
    $139–414

  7. Bus, train, shuttle

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Miami Amtrak Stationtrain train
    3. Take a shuttle bus from Miami, FL - International Airport to Key West, FLshuttle bus
    24h 53m
    $441–719

Myrtle Beach (MYR) to Key West International Airport (EYW) flights

Calendar34Weekly Planes
Duration5h 30mAverage Duration
Ticket$65Cheapest Price
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Questions & Answers

Map of how to get from Murrells Inlet to Key West.ExpandLaunch map view
  • Distance: 668.5 mi
  • Duration: 4h 46m

What companies run services between Murrells Inlet, SC, USA and Key West, FL, USA?

American Airlines and Delta fly from Myrtle Beach (MYR) to Key West International Airport (EYW) 5 times a day. Alternatively, you can take a vehicle from Murrells Inlet to N Roosevelt & 3rd Street via Myrtle Beach Bus Station, Wilmington Cape Fear Public Transit, Fayetteville Bus Station, Ft Lauderdale Broward Park & Ride, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 29h 48m.

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