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How to get fromMurrells Inlet to Port Saint Lucieby plane, bus, train, bus (Greyhound, Flixbus), car, or bus (Greyhound)

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There are 6 ways to get from Murrells Inlet to Port Saint Lucie by plane, bus, train, bus (Greyhound, Flixbus), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Fort Lauderdale–Hollywood International Airport, bus

    best
    1. Fly from Myrtle Beach (MYR) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane MYR - FLL
    2. Take the bus from Fort Lauderdale - Broward Blvd Park and Ride to Fort Piercebus bus
    6h 1m
    $231–503

  2. Drive  551.6 mi

    cheapest
    1. Drive from Murrells Inlet to Port Saint Luciecar car 551.6 mi
    9h 49m
    $101–146

  3. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Kissimmee Amtrak Stationtrain train
    3. Take the bus from Kissimmee -1471 East Osceola Parkway to Fort Piercebus bus
    15h 45m
    $200–408

  4. Bus

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the bus from Fayetteville Bus Station to West Palm Beach Bus Stationbus bus
    3. Take the bus from WPB ITC at BAY D to GATLIN BLVD at I-95 P/R LOTbus bus 95
    21h 5m
    $174–264

  5. Fly to Orlando, bus

    1. Fly from Myrtle Beach (MYR) to Orlando (MCO)plane plane MYR - MCO
    2. Take the bus from Kissimmee -1471 East Osceola Parkway to Fort Piercebus bus
    6h 32m
    $175–302

  6. Bus via Jacksonville (Greyhound)

    1. Take the bus from Myrtle Beach Bus Station to Sumter Bus Stopbus bus
    2. Take the bus from Sumter Bus Stop to Jacksonvillebus bus
    3. Take the bus from Jacksonville to Port St Luciebus bus
    22h 50m
    $168–266

Myrtle Beach (MYR) to Fort Lauderdale–Hollywood International Airport (FLL) flights

Calendar42Weekly Planes
Duration3h 38mAverage Duration
Ticket$83Cheapest Price
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Comparing Your Travel Options

Map of how to get from Murrells Inlet to Port Saint Lucie.ExpandLaunch map view
  • Distance: 641.6 mi
  • Duration: 6h 1m

What companies run services between Murrells Inlet, SC, USA and Port Saint Lucie, FL, USA?

You can take a vehicle from Murrells Inlet to SW PSL Blvd & SE Bayshore Blvd via Myrtle Beach Bus Station, Fayetteville Bus Station, West Palm Beach Bus Station, WPB ITC at BAY D, and SW Gatlin Blvd & SW Brescia St in around 21h 5m.

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