There are 7 ways to get from Murrysville to Chicago by bus, plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus, bus to Pittsburgh International Airport, fly to Chicago Midway International Airport
best- Take the bus from Old William Penn Hwy + Sardis Rd to Grant St + Liberty Ave FSbus
- Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus
- Fly from Pittsburgh International Airport (PIT) to Chicago Midway International Airport (MDW)plane PIT - MDW
5h 9mBus
cheapest- Take the bus from Pittsburgh Intermodal Station to Chicago Bus Stationbus Greyhound US0164
11h 40m$71–146Train (Amtrak)
- Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain Floridian
11h 21m$121–286Drive 472.2 mi
- Drive from Murrysville to Chicagocar 472.2 mi
7h 45m$87–125Bus, bus to Pittsburgh International Airport, fly to Chicago O'Hare International Airport
- Take the bus from Old William Penn Hwy + Sardis Rd to Grant St + Liberty Ave FSbus
- Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus
- Fly from Pittsburgh International Airport (PIT) to Chicago O'Hare International Airport (ORD)plane PIT - ORD
5h 35mTrain to Johnstown-Cambria County Airport, fly to Chicago O'Hare International Airport
- Take the train from Pittsburgh Amtrak Station to Johnstown Amtrak Stationtrain
- Fly from Johnstown-Cambria County Airport (JST) to Chicago O'Hare International Airport (ORD)plane JST - ORD
7h 8m$87–364Bus via Chicago (Flixbus)
- Take the bus from Pittsburgh Intermodal Station to Chicagobus FlixBus N2640
12h 57m$78–141
Murrysville to Chicago by bus and train (Amtrak)
Questions & Answers
The cheapest way to get from Murrysville to Chicago is to bus which costs $70 - $150 and takes 11h 40m.
The fastest way to get from Murrysville to Chicago is to train and fly which takes 7h 8m and costs $85 - $370.
No, there is no direct bus from Murrysville to Chicago station. However, there are services departing from Old William Penn Hwy + Sardis Rd and arriving at Chicago Bus Station via Pittsburgh Intermodal Station. The journey, including transfers, takes approximately 11h 40m.
No, there is no direct train from Murrysville station to Chicago station. However, there are services departing from Pittsburgh Amtrak Station and arriving at Chicago Union Station via . The journey, including transfers, takes approximately 11h 21m.
The distance between Murrysville and Chicago is 457 miles. The road distance is 475 miles.
The best way to get from Murrysville to Chicago without a car is to train which takes 11h 21m and costs $120 - $290.
It takes approximately 5h 9m to get from Murrysville to Chicago, including transfers.
Murrysville to Chicago bus services, operated by Greyhound USA, depart from Pittsburgh Intermodal Station.
Murrysville to Chicago train services, operated by Amtrak, depart from Pittsburgh Amtrak Station.
The best way to get from Murrysville to Chicago is to train which takes 11h 21m and costs $120 - $290. Alternatively, you can bus, which costs $70 - $150 and takes 11h 40m.
What companies run services between Murrysville, PA, USA and Chicago, IL, USA?
Amtrak operates a train from Pittsburgh Amtrak Station to Chicago Union Station once daily. Tickets cost $120–280 and the journey takes 9h 46m. Alternatively, Greyhound USA operates a bus from Pittsburgh Intermodal Station to Chicago Bus Station twice daily. Tickets cost $70–140 and the journey takes 10h 5m. Flixbus USA also services this route once daily.
- Website
- united.com
Flights from Pittsburgh International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 47m
- When
- Every day
- Estimated price
- $55–340
Flights from Pittsburgh International Airport to Chicago O'Hare International Airport via Toronto
- Ave. Duration
- 4h
- When
- Every day
- Estimated price
- $70–390
Flights from Pittsburgh International Airport to Chicago O'Hare International Airport via Washington Dulles
- Ave. Duration
- 4h 22m
- When
- Every day
- Estimated price
- $80–420
Flights from Johnstown-Cambria County Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 5m
- When
- Every day
- Estimated price
- $50–290
Flights from Johnstown-Cambria County Airport to Chicago O'Hare International Airport via Washington Dulles
- Ave. Duration
- 4h 23m
- When
- Every day
- Estimated price
- $60–330
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Pittsburgh Amtrak Station to Chicago Union Station
- Ave. Duration
- 9h 46m
- Frequency
- Once daily
- Estimated price
- $120–280
- Website
- Amtrak
Train from Pittsburgh Amtrak Station to Johnstown Amtrak Station
- Ave. Duration
- 1h 32m
- Frequency
- Once daily
- Estimated price
- $20–45
- Website
- Amtrak
- Phone
- +1-724-834-9282
- Website
- Westmoreland Transit
Bus from Old William Penn Hwy + Sardis Rd to Grant St + Liberty Ave FS
- Ave. Duration
- 36 min
- Frequency
- Twice daily
- Estimated price
- $1–6
- Website
- Westmoreland Transit
- Schedules at
- Westmoreland Transit Fixed-Route Bus Schedules
- Children 6-12
- $1–3
- Adults 13+
- $2–6
Bus from Old William Penn Hwy + Sardis Rd to Grant St + Liberty Ave FS
- Ave. Duration
- 36 min
- Frequency
- Twice daily
- Estimated price
- $1–6
- Website
- Westmoreland Transit
- Schedules at
- Westmoreland Transit Fixed-Route Bus Schedules
- Children 6-12
- $1–3
- Adults 13+
- $2–6
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More Questions & Answers
Murrysville to Chicago bus services, operated by Greyhound USA, arrive at Chicago Bus Station.
Chicago is 1h behind Murrysville. It is currently 7:14 AM in Murrysville and 6:14 AM in Chicago.
Murrysville to Chicago train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Murrysville to Chicago is 475 miles. It takes approximately 7h 45m to drive from Murrysville to Chicago.
There are 1275+ hotels available in Chicago.