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How to get fromMurrysville to Chicagoby bus, plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus (Flixbus)

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There are 7 ways to get from Murrysville to Chicago by bus, plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, bus to Pittsburgh International Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from Old William Penn Hwy + Sardis Rd to Grant St + Liberty Ave FSbus bus
    2. Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus bus
    3. Fly from Pittsburgh International Airport (PIT) to Chicago Midway International Airport (MDW)plane plane PIT - MDW
    5h 9m

  2. Bus

    cheapest
    1. Take the bus from Pittsburgh Intermodal Station to Chicago Bus Stationbus bus Greyhound US0164 / ...
    11h 55m
    $76–156

  3. Train (Amtrak)

    1. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train Floridian
    11h 21m
    $151–326

  4. Drive 472.2 mi

    1. Drive from Murrysville to Chicagocar car 472.2 mi
    7h 45m
    $87–125

  5. Bus, bus to Pittsburgh International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Old William Penn Hwy + Sardis Rd to Grant St + Liberty Ave FSbus bus
    2. Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus bus
    3. Fly from Pittsburgh International Airport (PIT) to Chicago O'Hare International Airport (ORD)plane plane PIT - ORD
    5h 35m

  6. Train to Johnstown-Cambria County Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Pittsburgh Amtrak Station to Johnstown Amtrak Stationtrain train
    2. Fly from Johnstown-Cambria County Airport (JST) to Chicago O'Hare International Airport (ORD)plane plane JST - ORD
    7h 3m
    $86–359

  7. Bus via Chicago

    1. Take the bus from Pittsburgh Intermodal Station to Chicagobus bus FlixBus N2640
    12h 57m
    $88–151

Murrysville to Chicago by bus and train (Amtrak)

Calendar7Weekly Services
Duration11h 21mAverage Duration
Ticket$151Cheapest Price
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Questions & Answers

Map of how to get from Murrysville to Chicago.ExpandLaunch map view
  • Distance: 454.7 mi
  • Duration: 5h 9m

What companies run services between Murrysville, PA, USA and Chicago, IL, USA?

Amtrak operates a train from Pittsburgh Amtrak Station to Chicago Union Station once daily. Tickets cost $150–320 and the journey takes 9h 46m. Alternatively, Jefferson Lines operates a bus from Pittsburgh Intermodal Station to Chicago Bus Station 3 times a day. Tickets cost $110–160 and the journey takes 10h 20m. Two other operators also service this route.

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Bus operators

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