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How to get fromMuscatine to Louisvilleby car, bus, train, taxi, or plane

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There are 7 ways to get from Muscatine to Louisville by car, bus, train, taxi, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive, bus

    best
    1. Drive from Muscatine to Galesburgcar car
    2. Take the bus from Galesburg to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus
    9h 30m
    $75–129

  2. Drive, train, bus

    1. Drive from Muscatine to Galesburg Amtrak Stationcar car
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Indianapolistrain train
    4. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus
    13h 15m
    $125–279

  3. Drive  435.1 mi

    1. Drive from Muscatine to Louisvillecar car 435.1 mi
    7h 36m
    $80–115

  4. Taxi to Quad City International Airport, fly

    1. Take the taxi from Muscatine to Moline-Airport-MLItaxi taxi
    2. Fly from Quad City International Airport (MLI) to Louisville International Airport (SDF)plane plane MLI - SDF
    5h 47m
    $191–722

  5. Taxi, bus

    1. Take the taxi from Muscatine to Moline Center Stationtaxi taxi
    2. Take the bus from Moline Center Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Louisville Bus Stationbus bus
    12h 4m
    $174–240

  6. Taxi, bus via Bloomington

    1. Take the taxi from Muscatine to Miller Containertaxi taxi
    2. Take the bus from Moline Center Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Bloomingtonbus bus
    4. Take the bus from Bloomington to Louisville Bus Stationbus bus
    15h 41m
    $160–220

  7. Drive to The Eastern Iowa Airport, fly

    1. Drive from Muscatine to Cedar-Rapids-Airport-CIDcar car
    2. Fly from The Eastern Iowa Airport (CID) to Louisville International Airport (SDF)plane plane CID - SDF
    6h 10m
    $112–618

Quad City International Airport (MLI) to Louisville International Airport (SDF) flights

Calendar82Weekly Planes
Duration5h 33mAverage Duration
Ticket$94Cheapest Price
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Questions & Answers

Map of how to get from Muscatine to Louisville.ExpandLaunch map view
  • Distance: 440.5 mi
  • Duration: 9h 30m

What companies run services between Muscatine, IA, USA and Louisville, KY, USA?

There is no direct connection from Muscatine to Louisville. However, you can drive to Galesburg, take the bus to Indianapolis Union Station, then take the bus to Louisville Bus Station. Alternatively, you can take a vehicle from Muscatine to Louisville Bus Station via Galesburg Amtrak Station, Chicago Union Station, Indianapolis, and Indianapolis Union Station in around 13h 15m.

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