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How to get fromMuscatine to St. Louisby car, bus, train, taxi, or plane

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There are 6 ways to get from Muscatine to St. Louis by car, bus, train, taxi, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive, bus, train (Amtrak)

    best
    1. Drive from Muscatine to Galesburg Amtrak Stationcar car
    2. Take the bus from Galesburg Amtrak Station to Springfieldbus bus
    3. Take the train from Springfield to St. Louistrain train
    6h 39m
    $63–119

  2. Drive  234.1 mi

    cheapest
    1. Drive from Muscatine to St. Louiscar car 234.1 mi
    5h 27m
    $43–62

  3. Taxi to Quad City International Airport, fly

    1. Take the taxi from Muscatine to Moline-Airport-MLItaxi taxi
    2. Fly from Quad City International Airport (MLI) to Lambert–St. Louis International Airport (STL)plane plane MLI - STL
    5h 16m
    $173–582

  4. Drive, bus

    1. Drive from Muscatine to Galesburg Amtrak Stationcar car
    2. Take the bus from Galesburg Amtrak Station to Springfieldbus bus
    3. Take the bus from Springfield SMTD Transfer Center to St Louis Bus Stationbus bus
    6h 52m
    $56–83

  5. Drive, bus, train via Bloomington

    1. Drive from Muscatine to Galesburgcar car
    2. Take the bus from Galesburg to Bloomington-Normalbus bus
    3. Take the train from Bloomington-Normal to St. Louistrain train
    6h 55m
    $61–135

  6. Drive to The Eastern Iowa Airport, fly

    1. Drive from Muscatine to Cedar-Rapids-Airport-CIDcar car
    2. Fly from The Eastern Iowa Airport (CID) to Lambert–St. Louis International Airport (STL)plane plane CID - STL
    6h 9m
    $89–498

Quad City International Airport (MLI) to Lambert–St. Louis International Airport (STL) flights

Calendar112Weekly Planes
Duration5h 45mAverage Duration
Ticket$74Cheapest Price
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Comparing Your Travel Options

Map of how to get from Muscatine to St. Louis.ExpandLaunch map view
  • Distance: 283.6 mi
  • Duration: 6h 39m

What companies run services between Muscatine, IA, USA and St. Louis, MO, USA?

There is no direct connection from Muscatine to St. Louis. However, you can drive to Galesburg Amtrak Station, take the bus to Springfield, walk to Springfield, then take the train to St. Louis. Alternatively, you can drive from Muscatine to St. Louis in around 5h 27m.

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