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How to get fromMyrtle Beach Airport (MYR) to Florida Keysby plane, bus, train, bus (Greyhound, Flixbus), car, or shuttle

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There are 5 ways to get from Myrtle Beach Airport (MYR) to Florida Keys by plane, bus, train, bus (Greyhound, Flixbus), car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Key West International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Key West International Airport (EYW)plane plane MYR - EYW
    7h 10m
    $427–694

  2. Drive 818.3 mi

    cheapest
    1. Drive from Myrtle Beach Airport (MYR) to Florida Keyscar car 818.3 mi
    14h 58m
    $150–216

  3. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Hollywood Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    24h 9m
    $251–523

  4. Bus

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Take the bus from Wilmington Cape Fear Public Transit to Fayetteville Bus Stationbus bus
    3. Take the bus from Fayetteville Bus Station to Ft Lauderdale Broward Park & Ridebus bus
    4. Take the bus from Ft Lauderdale Broward Park & Ride to Miami Airport Stationbus bus
    5. Take the bus from Miami Airport Station to Big Pine Keybus bus
    28h 46m
    $185–333

  5. Fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Myrtle Beach (MYR) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane MYR - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    7h 50m
    $316–664

Myrtle Beach (MYR) to Key West International Airport (EYW) flights

Calendar34Weekly Planes
Duration5h 30mAverage Duration
Ticket$66Cheapest Price
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Questions & Answers

Map of how to get from Myrtle Beach Airport (MYR) to Florida Keys.ExpandLaunch map view
  • Distance: 674.6 mi
  • Duration: 7h 10m

What companies run services between Myrtle Beach Airport (MYR), USA and Florida Keys, FL, USA?

American Airlines and Delta fly from Myrtle Beach (MYR) to Key West International Airport (EYW) 5 times a day. Alternatively, you can take a vehicle from Myrtle Beach Airport (MYR) to Florida Keys via Myrtle Beach Bus Station, Wilmington Cape Fear Public Transit, Fayetteville Bus Station, Ft Lauderdale Broward Park & Ride, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 28h 46m.

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