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How to get fromMyrtle Beach to Buffaloby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

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There are 8 ways to get from Myrtle Beach to Buffalo by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF)plane plane MYR - BUF
    5h 11m
    $117–642

  2. Fly to Toronto Pearson International Airport, bus

    cheapest
    1. Fly from Myrtle Beach (MYR) to Toronto Pearson International Airport (YYZ)plane plane MYR - YYZ
    2. Take the bus from Toronto Pearson Airport to Buffalobus bus
    8h 22m
    $87–368

  3. Bus

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the bus from Fayetteville Bus Station to Newark Penn Stationbus bus
    3. Take the bus from Newark Penn Station to Buffalobus bus
    23h 10m
    $173–281

  4. Bus, train via Fayetteville

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the train from Fayetteville Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    24h 58m
    $568–881

  5. Drive  759 mi

    1. Drive from Myrtle Beach to Buffalocar car 759 mi
    15h 33m
    $139–201

  6. Fly to Rochester, bus

    1. Fly from Myrtle Beach (MYR) to Rochester (ROC)plane plane MYR - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    4h 50m
    $171–806

  7. Bus via Raleigh

    1. Take the bus from Myrtle Beach Bus Station to Raleigh Bus Stationbus bus
    2. Take the bus from Raleigh Bus Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Buffalobus bus
    24h 30m
    $194–488

  8. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    27h 8m
    $658–1,046

Myrtle Beach to Buffalo by bus

Calendar4Weekly Buses
Duration23h 10mAverage Duration
Ticket$173Cheapest Price
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Comparing Your Travel Options

Map of how to get from Myrtle Beach to Buffalo.ExpandLaunch map view
  • Distance: 651.8 mi
  • Duration: 5h 11m

What companies run services between Myrtle Beach, SC, USA and Buffalo, NY, USA?

Southwest Airlines, Delta, and two other airlines fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a bus from Myrtle Beach Bus Station to Buffalo via Fayetteville Bus Station and Newark Penn Station in around 23h 10m.

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