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How to get fromMyrtle Beach to Buffaloby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

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There are 7 ways to get from Myrtle Beach to Buffalo by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF)plane plane MYR - BUF
    5h 16m
    $107–592

  2. Bus

    1. Take the bus from Myrtle Beach Bus Station to Raleigh Bus Stationbus bus
    2. Take the bus from Raleigh Bus Station to Newark Penn Stationbus bus
    3. Take the bus from Newark Penn Station to Buffalobus bus
    23h 25m
    $164–273

  3. Bus, train via Fayetteville

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the train from Fayetteville Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    24h 28m
    $254–618

  4. Drive  759 mi

    1. Drive from Myrtle Beach to Buffalocar car 759 mi
    15h 33m
    $139–201

  5. Fly to Rochester, bus

    1. Fly from Myrtle Beach (MYR) to Rochester (ROC)plane plane MYR - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    4h 50m
    $161–755

  6. Bus via Columbus

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the bus from Fayetteville to Winston-Salembus bus
    3. Take the bus from Winston Salem to Columbusbus bus
    4. Take the bus from Columbus - Mound St to Buffalo, NYbus bus
    26h 5m
    $123–243

  7. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    26h 43m
    $286–714

Myrtle Beach to Buffalo by bus

Calendar7Weekly Buses
Duration23h 25mAverage Duration
Ticket$164Cheapest Price
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Comparing Your Travel Options

Map of how to get from Myrtle Beach to Buffalo.ExpandLaunch map view
  • Distance: 651.8 mi
  • Duration: 5h 16m

What companies run services between Myrtle Beach, SC, USA and Buffalo, NY, USA?

Southwest Airlines, American Airlines, and Delta fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a bus from Myrtle Beach Bus Station to Buffalo via Raleigh Bus Station and Newark Penn Station in around 23h 25m.

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