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How to get fromMyrtle Beach to Chicagoby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

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There are 8 ways to get from Myrtle Beach to Chicago by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Chicago Midway International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Chicago Midway International Airport (MDW)plane plane MYR - MDW
    2h 53m
    $79–359

  2. Fly to Chicago O'Hare International Airport

    cheapest
    1. Fly from Myrtle Beach (MYR) to Chicago O'Hare International Airport (ORD)plane plane MYR - ORD
    3h 24m
    $69–319

  3. Bus via Atlanta

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus Greyhound US0641S
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    25h 55m
    $152–297

  4. Bus, train via Wilson

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Take the bus from Wilmington Amtrak Station to Wilsonbus bus
    3. Take the train from Wilson to Petersburg Amtrak Stationtrain train
    4. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    31h 7m
    $321–700

  5. Drive 895.4 mi

    1. Drive from Myrtle Beach to Chicagocar car 895.4 mi
    16h 31m
    $164–236

  6. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Petersburg Amtrak Stationtrain train
    3. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    32h 17m
    $349–796

  7. Bus

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the bus from Fayetteville to Winston-Salembus bus
    3. Take the bus from Winston Salem(Trans Center) to Columbus - Mound Stbus bus
    4. Take the bus from Columbus - Mound St to Chicagobus bus
    32h 30m
    $140–313

  8. Bus, train #2

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the train from Fayetteville Amtrak Station to Selma Stationtrain train
    3. Take the train from Selma Station to Carytrain train
    4. Take the train from Cary to Chicago Union Stationtrain train
    38h 58m
    $357–804

Myrtle Beach to Chicago by bus

Calendar7Weekly Buses
Duration25h 55mAverage Duration
Ticket$152Cheapest Price
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Questions & Answers

Map of how to get from Myrtle Beach to Chicago.ExpandLaunch map view
  • Distance: 751.8 mi
  • Duration: 2h 53m

What companies run services between Myrtle Beach, SC, USA and Chicago, IL, USA?

Southwest Airlines flies from Myrtle Beach (MYR) to Chicago Midway International Airport (MDW) 3 times a day. Alternatively, you can take a bus from Myrtle Beach Bus Station to Chicago Bus Station via Atlanta Bus Station in around 25h 55m.

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