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How to get fromMyrtle Beach to Chicagoby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

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There are 7 ways to get from Myrtle Beach to Chicago by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Chicago Midway International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Chicago Midway International Airport (MDW)plane plane MYR - MDW
    2h 53m
    $79–389

  2. Fly to Chicago O'Hare International Airport

    cheapest
    1. Fly from Myrtle Beach (MYR) to Chicago O'Hare International Airport (ORD)plane plane MYR - ORD
    3h 26m
    $64–319

  3. Bus via Atlanta

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus Greyhound US0641S
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    25h 55m
    $158–270

  4. Bus, train via Raleigh

    1. Take the bus from Myrtle Beach Bus Station to Raleigh Bus Stationbus bus Greyhound US0645S
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train Floridian
    30h 22m
    $298–707

  5. Drive  895.5 mi

    1. Drive from Myrtle Beach to Chicagocar car 895.5 mi
    16h 30m
    $164–237

  6. Bus

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the bus from Fayetteville to Winston-Salembus bus
    3. Take the bus from Winston Salem to Columbusbus bus
    4. Take the bus from N Wilson Rd & Ferrell Pl - Columbus to Chicagobus bus
    26h 25m
    $118–242

  7. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Petersburg Amtrak Stationtrain train
    3. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    31h 57m
    $326–794

Myrtle Beach to Chicago by bus

Calendar7Weekly Buses
Duration25h 55mAverage Duration
Ticket$158Cheapest Price
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Comparing Your Travel Options

Map of how to get from Myrtle Beach to Chicago.ExpandLaunch map view
  • Distance: 751.8 mi
  • Duration: 2h 53m

What companies run services between Myrtle Beach, SC, USA and Chicago, IL, USA?

Southwest Airlines flies from Myrtle Beach (MYR) to Chicago Midway International Airport (MDW) twice daily. Alternatively, you can take a bus from Myrtle Beach Bus Station to Chicago Bus Station via Atlanta Bus Station in around 25h 55m.

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Want to know more about travelling around United States

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