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How to get fromMyrtle Beach to Des Moinesby plane, bus (Greyhound, Flixbus, Amtrak), bus, train, car, or bus (Greyhound, Flixbus)

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There are 6 ways to get from Myrtle Beach to Des Moines by plane, bus (Greyhound, Flixbus, Amtrak), bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Myrtle Beach (MYR) to Des Moines (DSM)plane plane MYR - DSM
    4h 51m
    $169–735

  2. Bus via Carbondale

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Carbondale Intermodal Stationbus bus
    3. Take the bus from Carbondale to St. Louisbus bus
    4. Take the bus from St Louis Bus Station to Des Moinesbus bus
    30h 41m
    $208–408

  3. Bus, train via Galesburg

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Take the bus from Wilmington Amtrak Station to Wilsonbus bus
    3. Take the train from Wilson to Petersburg Amtrak Stationtrain train
    4. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    5. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    6. Take the bus from Galesburg to Des Moinesbus bus
    40h 38m
    $462–943

  4. Drive 1,183.8 mi

    1. Drive from Myrtle Beach to Des Moinescar car 1,183.8 mi
    21h 19m
    $216–313

  5. Bus

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Des Moinesbus bus
    31h
    $208–408

  6. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Raleigh Bus Stationbus bus
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    43h 54m
    $474–986

Myrtle Beach to Des Moines by bus

Calendar5Weekly Buses
Duration30h 41mAverage Duration
Ticket$208Cheapest Price
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Questions & Answers

Map of how to get from Myrtle Beach to Des Moines.ExpandLaunch map view
  • Distance: 978.7 mi
  • Duration: 4h 51m

What companies run services between Myrtle Beach, SC, USA and Des Moines, IA, USA?

Delta, Southwest Airlines, and two other airlines fly from Myrtle Beach (MYR) to Des Moines (DSM) every 3 hours. Alternatively, you can take a bus from Myrtle Beach Bus Station to Des Moines via Atlanta Bus Station, Carbondale, St. Louis, and St Louis Bus Station in around 30h 41m.

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