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How to get fromMyrtle Beach to Des Moinesby plane, bus (Greyhound), bus, train, or car

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There are 7 ways to get from Myrtle Beach to Des Moines by plane, bus (Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Myrtle Beach (MYR) to Des Moines (DSM)plane plane MYR - DSM
    4h 47m
    $109–455

  2. Bus via Atlanta (Greyhound)

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    32h 40m
    $213–350

  3. Bus, train via Wilson

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Take the bus from Wilmington Amtrak Station to Wilsonbus bus
    3. Take the train from Wilson to Petersburg Amtrak Stationtrain train
    4. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    5. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    6. Take the bus from Galesburg to Des Moinesbus bus
    40h 38m
    $387–844

  4. Drive  1,183.8 mi

    1. Drive from Myrtle Beach to Des Moinescar car 1,183.8 mi
    21h 19m
    $216–313

  5. Bus

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the bus from Fayetteville to Winston-Salembus bus
    3. Take the bus from Winston Salem to Columbusbus bus
    4. Take the bus from N Wilson Rd & Ferrell Pl - Columbus to Chicagobus bus
    5. Take the bus from Chicago Bus Station to Des Moinesbus bus
    39h 55m
    $205–385

  6. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Petersburg Amtrak Stationtrain train
    3. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    5. Take the bus from Galesburg to Des Moinesbus bus
    41h 48m
    $421–944

  7. Bus, train #2

    1. Take the bus from Myrtle Beach Bus Station to Raleigh Bus Stationbus bus
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    43h 56m
    $405–850

Myrtle Beach to Des Moines by bus (Greyhound)

Calendar7Weekly Buses
Duration32h 40mAverage Duration
Ticket$213Cheapest Price
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Questions & Answers

Map of how to get from Myrtle Beach to Des Moines.ExpandLaunch map view
  • Distance: 978.7 mi
  • Duration: 4h 47m

What companies run services between Myrtle Beach, SC, USA and Des Moines, IA, USA?

American Airlines, Delta, and two other airlines fly from Myrtle Beach (MYR) to Des Moines (DSM) every 3 hours. Alternatively, you can take a bus from Myrtle Beach Bus Station to Des Moines via Atlanta Bus Station and Indianapolis Union Station in around 32h 40m.

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