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How to get fromMyrtle Beach to Florida Keysby plane, bus, train, bus (Greyhound, Flixbus), car, or shuttle

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There are 6 ways to get from Myrtle Beach to Florida Keys by plane, bus, train, bus (Greyhound, Flixbus), car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Myrtle Beach to Key West International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Key West International Airport (EYW)plane plane MYR - EYW
    7h 44m
    $149–408

  2. Bus

    cheapest
    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Take the bus from Wilmington Cape Fear Public Transit to Fayetteville Bus Stationbus bus
    3. Take the bus from Fayetteville Bus Station to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    27h 35m
    $147–274

  3. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Hollywood Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    24h 2m
    $207–451

  4. Drive  818.9 mi

    1. Drive from Myrtle Beach to Florida Keyscar car 818.9 mi
    14h 58m
    $150–216

  5. Fly Myrtle Beach to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Myrtle Beach (MYR) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane MYR - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    8h 4m
    $324–638

  6. Bus to Wilmington International Airport, fly to Key West International Airport

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Fly from Wilmington International Airport (ILM) to Key West International Airport (EYW)plane plane ILM - EYW
    10h 27m
    $157–432

Myrtle Beach to Florida Keys by bus, train, and foot

Calendar7Weekly Services
Duration24h 2mAverage Duration
Ticket$207Cheapest Price
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Questions & Answers

Map of how to get from Myrtle Beach to Florida Keys.ExpandLaunch map view
  • Distance: 677.4 mi
  • Duration: 7h 44m

What companies run services between Myrtle Beach, SC, USA and Florida Keys, FL, USA?

American Airlines and Delta fly from Myrtle Beach (MYR) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from Myrtle Beach Bus Station to Florida Keys via Wilmington Cape Fear Public Transit, Fayetteville Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 27h 35m.

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