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How to get fromMyrtle Beach to Fort Myersby plane, bus, train, car, or bus (Greyhound, Flixbus)

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There are 9 ways to get from Myrtle Beach to Fort Myers by plane, bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Myrtle Beach to Ft. Myers

    best
    1. Fly from Myrtle Beach (MYR) to Ft. Myers (RSW)plane plane MYR - RSW
    6h 34m
    $95–469

  2. Bus, train via Jacksonville

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Jacksonvilletrain train
    3. Take the bus from Jacksonville to Wildwood Amtrak Stationbus bus
    4. Take the bus from Wildwood to Fort Myersbus bus
    17h 52m
    $165–304

  3. Drive  623 mi

    1. Drive from Myrtle Beach to Fort Myerscar car 623 mi
    11h 41m
    $114–165

  4. Fly Myrtle Beach to Fort Lauderdale–Hollywood International Airport, bus

    1. Fly from Myrtle Beach (MYR) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane MYR - FLL
    2. Take the bus from Fort Lauderdale International Airport to Fort Myers Bus Stopbus bus
    5h 33m
    $171–454

  5. Fly Myrtle Beach to Tampa, bus

    1. Fly from Myrtle Beach (MYR) to Tampa (TPA)plane plane MYR - TPA
    2. Take the bus from Tampa Bus Station to Fort Myers Bus Stopbus bus
    6h 58m
    $123–386

  6. Fly Myrtle Beach to Orlando, bus

    1. Fly from Myrtle Beach (MYR) to Orlando (MCO)plane plane MYR - MCO
    2. Take the bus from Orlando to Fort Myers Bus Stopbus bus
    9h 9m
    $144–276

  7. Bus to Wilmington International Airport, fly to Ft. Myers

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Fly from Wilmington International Airport (ILM) to Ft. Myers (RSW)plane plane ILM - RSW
    6h 45m
    $124–542

  8. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Winter Park Amtrak Stationtrain train
    3. Take the bus from Orlando to Fort Myers Bus Stopbus bus
    18h 58m
    $137–306

  9. Bus

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the bus from Fayetteville Bus Station to Orlando Bus Stationbus bus
    3. Take the bus from Orlando Bus Station to Fort Myers Bus Stopbus bus
    20h 5m
    $134–217

Myrtle Beach to Fort Myers by bus and train

Calendar7Weekly Services
Duration18h 58mAverage Duration
Ticket$137Cheapest Price
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Comparing Your Travel Options

Map of how to get from Myrtle Beach to Fort Myers.ExpandLaunch map view
  • Distance: 540 mi
  • Duration: 6h 34m

What companies run services between Myrtle Beach, SC, USA and Fort Myers, FL, USA?

Southwest Airlines, Delta, and American Airlines fly from Myrtle Beach (MYR) to Ft. Myers (RSW) every 4 hours. Alternatively, you can take a bus from Myrtle Beach Bus Station to Fort Myers Bus Stop via Fayetteville Bus Station and Orlando Bus Station in around 20h 5m.

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