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How to get fromMyrtle Beach to Gainesvilleby plane, bus, train, bus (Greyhound, Flixbus), or car

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There are 6 ways to get from Myrtle Beach to Gainesville by plane, bus, train, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Gainesville Regional Airport

    best
    1. Fly from Myrtle Beach (MYR) to Gainesville Regional Airport (GNV)plane plane MYR - GNV
    5h 1m
    $69–356

  2. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Jacksonvilletrain train
    3. Take the bus from Jacksonville to Gainesvillebus bus
    11h 16m
    $159–255

  3. Bus

    1. Take the bus from Myrtle Beach Bus Station to Camdenbus bus
    2. Take the bus from Camden to Jacksonvillebus bus
    3. Take the bus from Jacksonville to Gainesvillebus bus
    14h 14m
    $91–137

  4. Drive  395.2 mi

    1. Drive from Myrtle Beach to Gainesvillecar car 395.2 mi
    7h 34m
    $73–105

  5. Fly to Orlando, bus

    1. Fly from Myrtle Beach (MYR) to Orlando (MCO)plane plane MYR - MCO
    2. Take the bus from Orlando - RedCoach Station, FL to University of Florida - 1956 Gale Lemerand Drbus bus
    5h 31m
    $143–266

  6. Fly to Jacksonville, bus

    1. Fly from Myrtle Beach (MYR) to Jacksonville (JAX)plane plane MYR - JAX
    2. Take the bus from Jacksonville to Gainesvillebus bus
    7h 45m
    $83–403

Myrtle Beach to Gainesville by bus and train

Calendar6Weekly Services
Duration11h 16mAverage Duration
Ticket$159Cheapest Price
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Comparing Your Travel Options

Map of how to get from Myrtle Beach to Gainesville.ExpandLaunch map view
  • Distance: 349.3 mi
  • Duration: 5h 1m

What companies run services between Myrtle Beach, SC, USA and Gainesville, FL, USA?

Delta and American Airlines fly from Myrtle Beach (MYR) to Gainesville Regional Airport (GNV) 5 times a day. Alternatively, you can take a bus from Myrtle Beach Bus Station to Gainesville via Camden and Jacksonville in around 14h 14m.

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Want to know more about travelling around United States

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