Rome2Rio

How to get fromMyrtle Beach to Great Smoky Mountainsby plane, car, bus, or train

Find Transport to Great Smoky Mountains

See all options

There are 8 ways to get from Myrtle Beach to Great Smoky Mountains by plane, car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport, drive

    best
    1. Fly from Myrtle Beach (MYR) to Mcghee Tyson Airport (TYS)plane plane MYR - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    5h 23m
    $102–530

  2. Drive 360.9 mi

    cheapest
    1. Drive from Myrtle Beach to Great Smoky Mountainscar car 360.9 mi
    7h 27m
    $66–96

  3. Bus, drive (Greyhound)

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Take the bus from Wilmington Cape Fear Public Transit to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Asheville, NCbus bus
    4. Drive from Asheville, NC to Great Smoky Mountainscar car
    13h 43m
    $80–157

  4. Fly to Asheville Regional Airport, drive

    1. Fly from Myrtle Beach (MYR) to Asheville Regional Airport (AVL)plane plane MYR - AVL
    2. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    5h 20m
    $66–306

  5. Fly to Hartsfield-Jackson Atlanta International Airport, drive

    1. Fly from Myrtle Beach (MYR) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane MYR - ATL
    2. Drive from Atlanta-Airport-ATL to Great Smoky Mountainscar car
    5h 35m
    $267–819

  6. Bus, drive via Camden

    1. Take the bus from Myrtle Beach Bus Station to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    4. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    5. Drive from Asheville, NC to Great Smoky Mountainscar car
    13h 53m
    $71–161

  7. Bus, train, drive

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Selma Stationtrain train
    3. Take the train from Selma Station to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    5. Drive from Asheville, NC to Great Smoky Mountainscar car
    17h 6m
    $159–323

  8. Bus, drive #2 (Greyhound)

    1. Take the bus from Myrtle Beach Bus Station to Raleigh Bus Stationbus bus
    2. Take the bus from Raleigh Bus Station to Asheville, NCbus bus
    3. Drive from Asheville, NC to Great Smoky Mountainscar car
    18h 23m
    $116–225

Myrtle Beach (MYR) to Mcghee Tyson Airport (TYS) flights

Calendar67Weekly Planes
Duration4h 39mAverage Duration
Ticket$80Cheapest Price
See schedules

Questions & Answers

Map of how to get from Myrtle Beach to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 384.9 mi
  • Duration: 5h 23m

What companies run services between Myrtle Beach, SC, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Myrtle Beach to Great Smoky Mountains. However, you can take the taxi to Myrtle Beach (MYR) airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take a bus from Myrtle Beach Bus Station to Great Smoky Mountains via Wilmington Cape Fear Public Transit, Raleigh Bus Station, and Asheville, NC in around 13h 43m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound