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How to get fromMyrtle Beach to Harrisburgby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 6 ways to get from Myrtle Beach to Harrisburg by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Myrtle Beach (MYR) to Harrisburg International Airport (MDT)plane plane MYR - MDT
    2h 44m
    $64–328

  2. Bus via Wilmington

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Take the bus from Wilmington Cape Fear Public Transit to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Baltimore Downtown Bus Stationbus bus
    4. Take the bus from Baltimore Downtown Bus Station to Harrisburg Bus Stationbus bus
    15h 20m
    $82–169

  3. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to 30th Street Stationtrain train
    3. Take the train from 30th Street Station to Harrisburgtrain train
    18h 45m
    $235–518

  4. Drive 526 mi

    1. Drive from Myrtle Beach to Harrisburgcar car 526 mi
    9h 59m
    $96–139

  5. Bus

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the bus from Fayetteville Bus Station to Baltimore Downtown Bus Stationbus bus
    3. Take the bus from Baltimore Downtown Bus Station to Harrisburg Bus Stationbus bus
    20h 30m
    $124–221

  6. Bus, train via Washington

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the train from Fayetteville Amtrak Station to Washington Union Stationtrain train
    3. Take the bus from Washington Union Station to Harrisburg Bus Stationbus bus
    20h 38m
    $174–354

Myrtle Beach to Harrisburg by bus

Calendar7Weekly Buses
Duration15h 20mAverage Duration
Ticket$82Cheapest Price
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Questions & Answers

Map of how to get from Myrtle Beach to Harrisburg.ExpandLaunch map view
  • Distance: 479.9 mi
  • Duration: 2h 44m

What companies run services between Myrtle Beach, SC, USA and Harrisburg, Dauphin County, PA, USA?

Allegiant Air, United Airlines, and American Airlines fly from Myrtle Beach (MYR) to Harrisburg International Airport (MDT) twice daily. Alternatively, you can take a bus from Myrtle Beach Bus Station to Harrisburg Bus Station via Wilmington Cape Fear Public Transit, Raleigh Bus Station, and Baltimore Downtown Bus Station in around 15h 20m.

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