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How to get fromMyrtle Beach to Key Westby plane, bus, train, shuttle, bus (Greyhound, Flixbus), or car

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There are 5 ways to get from Myrtle Beach to Key West by plane, bus, train, shuttle, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Myrtle Beach

    best
    1. Fly from Myrtle Beach (MYR) to Key West International Airport (EYW)plane plane MYR - EYW
    5h 10m
    $88–367

  2. Bus, train, shuttle

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Miami Amtrak Stationtrain train
    3. Take a shuttle bus from Miami, FL - International Airport to Key West, FLshuttle bus
    24h 12m
    $349–623

  3. Bus

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the bus from Fayetteville Bus Station to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    26h 11m
    $156–256

  4. Drive  834.4 mi

    1. Drive from Myrtle Beach to Key Westcar car 834.4 mi
    15h 21m
    $153–220

  5. Bus to Wilmington International Airport, fly

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Fly from Wilmington International Airport (ILM) to Key West International Airport (EYW)plane plane ILM - EYW
    7h 51m
    $97–380

Myrtle Beach to Key West by bus, train, foot, tram, and shuttle

Calendar7Weekly Services
Duration24h 12mAverage Duration
Ticket$349Cheapest Price
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Comparing Your Travel Options

Map of how to get from Myrtle Beach to Key West.ExpandLaunch map view
  • Distance: 658.2 mi
  • Duration: 5h 10m

What companies run services between Myrtle Beach, SC, USA and Key West, FL, USA?

Delta and American Airlines fly from Myrtle Beach (MYR) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from Myrtle Beach Bus Station to N Roosevelt & 3rd Street via Fayetteville Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 26h 11m.

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