Rome2Rio

How to get fromMyrtle Beach to Key West (Island)by plane, bus, train, bus (Greyhound, Flixbus), or car

Find Transport to Key West (Island)

See all options

There are 5 ways to get from Myrtle Beach to Key West (Island) by plane, bus, train, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Myrtle Beach

    best
    1. Fly from Myrtle Beach (MYR) to Key West International Airport (EYW)plane plane MYR - EYW
    4h 34m
    $82–374

  2. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Hollywood Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Key West Airportbus bus
    23h 27m
    $398–627

  3. Bus

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the bus from Fayetteville Bus Station to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Key West Airportbus bus
    24h 45m
    $174–265

  4. Drive  834.4 mi

    1. Drive from Myrtle Beach to Key Westcar car 834.4 mi
    15h 21m
    $153–220

  5. Bus to Wilmington International Airport, fly

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Fly from Wilmington International Airport (ILM) to Key West International Airport (EYW)plane plane ILM - EYW
    7h 14m
    $88–378

Myrtle Beach to Key West (Island) by bus and train

Calendar7Weekly Services
Duration23h 27mAverage Duration
Ticket$398Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Myrtle Beach to Key West (Island).ExpandLaunch map view
  • Distance: 656.2 mi
  • Duration: 4h 34m

What companies run services between Myrtle Beach, SC, USA and Key West (Island), FL, USA?

American Airlines and Delta fly from Myrtle Beach (MYR) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from Myrtle Beach Bus Station to Key West Airport via Fayetteville Bus Station and Miami Airport Station in around 24h 45m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There