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How to get fromMyrtle Beach to Key West (Island)by plane, bus, train, bus (Greyhound, Flixbus), or car

Find Transport to Key West (Island)

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There are 5 ways to get from Myrtle Beach to Key West (Island) by plane, bus, train, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Myrtle Beach

    best
    1. Fly from Myrtle Beach (MYR) to Key West International Airport (EYW)plane plane MYR - EYW
    4h 39m
    $72–334

  2. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Hollywood Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Key West Airportbus bus
    23h 22m
    $202–440

  3. Bus

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Take the bus from Wilmington Cape Fear Public Transit to Fayetteville Bus Stationbus bus
    3. Take the bus from Fayetteville Bus Station to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Key West Airportbus bus
    26h 55m
    $164–268

  4. Drive  834.4 mi

    1. Drive from Myrtle Beach to Key Westcar car 834.4 mi
    15h 21m
    $153–220

  5. Bus to Wilmington International Airport, fly

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Fly from Wilmington International Airport (ILM) to Key West International Airport (EYW)plane plane ILM - EYW
    7h 17m
    $81–357

Myrtle Beach to Key West (Island) by bus and train

Calendar7Weekly Services
Duration23h 22mAverage Duration
Ticket$202Cheapest Price
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Comparing Your Travel Options

Map of how to get from Myrtle Beach to Key West (Island).ExpandLaunch map view
  • Distance: 656.2 mi
  • Duration: 4h 39m

What companies run services between Myrtle Beach, SC, USA and Key West (Island), FL, USA?

American Airlines and Delta fly from Myrtle Beach (MYR) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from Myrtle Beach Bus Station to Key West Airport via Wilmington Cape Fear Public Transit, Fayetteville Bus Station, and Miami Airport Station in around 26h 55m.

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