What is the cheapest way to get from Myrtle Beach to Knoxville?

The cheapest way to get from Myrtle Beach to Knoxville is to drive which costs $70 - $110 and takes 7h 35m.

What is the fastest way to get from Myrtle Beach to Knoxville?

The fastest way to get from Myrtle Beach to Knoxville is to fly which takes 3h 46m and costs $170 - $850.

How far is it from Myrtle Beach to Knoxville?

The distance between Myrtle Beach and Knoxville is 341 miles. The road distance is 403.4 miles.

How long does it take to get from Myrtle Beach to Knoxville?

It takes approximately 3h 46m to get from Myrtle Beach to Knoxville, including transfers.

Can I drive from Myrtle Beach to Knoxville?

Yes, the driving distance between Myrtle Beach to Knoxville is 403 miles. It takes approximately 7h 35m to drive from Myrtle Beach to Knoxville.

Where can I stay near Knoxville?

There are 325+ hotels available in Knoxville.

Myrtle Beach to Knoxville - 5 ways to travel via train, plane, bus, and shuttle

How to get fromMyrtle Beach to Knoxville

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There are 5 ways to get from Myrtle Beach to Knoxville by plane, bus, shuttle, car, taxi, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Fly
best
1. Fly from Myrtle Beach (MYR) to Mcghee Tyson Airport (TYS)plane MYR - TYS
3h 46m
$177–834
Drive 401.1 mi
cheapest
1. Drive from Myrtle Beach to Knoxvillecar 401.1 mi
7h 35m
$74–106
Bus, shuttle, drive
1. Take the bus from Myrtle Beach Bus Station to Camdenbus
2. Take the bus from Camden to Charlotte Bus Stationbus
3. Take the bus from Charlotte to Boonebus
4. Take a shuttle bus from Boone to Black Bear Resortshuttle
5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle
6. Drive from Hot Springs to Knoxvillecar
15h 24m
$283–316
Bus, taxi, shuttle, drive
1. Take the bus from Myrtle Beach Bus Station to Camdenbus
2. Take the bus from Camden to Charlotte Bus Stationbus
3. Take the bus from Charlotte to Boonebus
4. Take the taxi from Boone to Black Bear Resorttaxi
5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle
6. Drive from Hot Springs to Chilhowee at Holstoncar
15h 38m
$318–381
Bus, train, taxi, shuttle, drive
1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus
2. Take the train from Fayetteville Amtrak Station to Selma Stationtrain
3. Take the train from Selma Station to High Pointtrain
4. Take the bus from Forsyth Hospital to Boonebus
5. Take the taxi from Boone to Black Bear Resorttaxi
6. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle
7. Drive from Hot Springs to Knoxvillecar
18h 7m
$401–522

Myrtle Beach (MYR) to Mcghee Tyson Airport (TYS) flights

76Weekly Planes

4h 23mAverage Duration

$113Cheapest Price

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Comparing Your Travel Options

Map of how to get from Myrtle Beach to Knoxville.

Launch map view

Distance: 338.5 mi
Duration: 3h 46m

What companies run services between Myrtle Beach, SC, USA and Knoxville, TN, USA?

Delta, American Airlines, and two other airlines fly from Myrtle Beach (MYR) to Mcghee Tyson Airport (TYS) every 2 hours.

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