What is the cheapest way to get from Myrtle Beach to Knoxville?

The cheapest way to get from Myrtle Beach to Knoxville is to drive which costs $70 - $110 and takes 7h 35m.

What is the fastest way to get from Myrtle Beach to Knoxville?

The fastest way to get from Myrtle Beach to Knoxville is to fly which takes 3h 36m and costs $160 - $800.

How far is it from Myrtle Beach to Knoxville?

The distance between Myrtle Beach and Knoxville is 341 miles. The road distance is 403.4 miles.

How long does it take to get from Myrtle Beach to Knoxville?

It takes approximately 3h 36m to get from Myrtle Beach to Knoxville, including transfers.

Can I drive from Myrtle Beach to Knoxville?

Yes, the driving distance between Myrtle Beach to Knoxville is 403 miles. It takes approximately 7h 35m to drive from Myrtle Beach to Knoxville.

Where can I stay near Knoxville?

There are 326+ hotels available in Knoxville.

Myrtle Beach to Knoxville - 3 ways to travel via plane, bus, shuttle, and car

How to get fromMyrtle Beach to Knoxville

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There are 3 ways to get from Myrtle Beach to Knoxville by plane, bus, shuttle, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Fly
best
1. Fly from Myrtle Beach (MYR) to Mcghee Tyson Airport (TYS)plane MYR - TYS
3h 36m
$167–784
Drive 401.1 mi
cheapest
1. Drive from Myrtle Beach to Knoxvillecar 401.1 mi
7h 35m
$74–106
Bus, shuttle, drive
1. Take the bus from Myrtle Beach Bus Station to Camdenbus
2. Take the bus from Camden to Charlotte Bus Stationbus
3. Take the bus from Charlotte to Boonebus
4. Take a shuttle bus from Boone to Black Bear Resortshuttle
5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle
6. Drive from Hot Springs to Knoxvillecar
15h 24m
$282–315

Myrtle Beach (MYR) to Mcghee Tyson Airport (TYS) flights

87Weekly Planes

5h 1mAverage Duration

$102Cheapest Price

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Comparing Your Travel Options

Map of how to get from Myrtle Beach to Knoxville.

Launch map view

Distance: 338.5 mi
Duration: 3h 36m

What companies run services between Myrtle Beach, SC, USA and Knoxville, TN, USA?

Delta, American Airlines, and Southwest Airlines fly from Myrtle Beach (MYR) to Mcghee Tyson Airport (TYS) every 2 hours.

Airlines

Bus operators

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