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How to get fromMyrtle Beach to Knoxvilleby plane, bus, shuttle, car, or taxi

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There are 4 ways to get from Myrtle Beach to Knoxville by plane, bus, shuttle, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Myrtle Beach (MYR) to Mcghee Tyson Airport (TYS)plane plane MYR - TYS
    3h 48m
    $147–634

  2. Drive 401.1 mi

    cheapest
    1. Drive from Myrtle Beach to Knoxvillecar car 401.1 mi
    7h 35m
    $74–106

  3. Bus, shuttle, drive

    1. Take the bus from Myrtle Beach Bus Station to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte to Boonebus bus
    4. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    6. Drive from Hot Springs to Knoxvillecar car
    15h 24m
    $314–367

  4. Bus, taxi, shuttle, drive

    1. Take the bus from Myrtle Beach to Charlottebus bus
    2. Take the bus from Charlotte Airport to ASU Peacock Hall Boonebus bus
    3. Take the taxi from ASU Peacock Hall Boone to Black Bear Resorttaxi taxi
    4. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    5. Drive from Hot Springs to Chilhowee at Holstoncar car
    16h 5m
    $449–543

Myrtle Beach (MYR) to Mcghee Tyson Airport (TYS) flights

Calendar67Weekly Planes
Duration4h 39mAverage Duration
Ticket$84Cheapest Price
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Questions & Answers

Map of how to get from Myrtle Beach to Knoxville.ExpandLaunch map view
  • Distance: 338.5 mi
  • Duration: 3h 48m

What companies run services between Myrtle Beach, SC, USA and Knoxville, TN, USA?

American Airlines, Delta, and two other airlines fly from Myrtle Beach (MYR) to Mcghee Tyson Airport (TYS) every 3 hours.

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