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How to get fromMyrtle Beach to Lafayetteby plane, shuttle, bus (Greyhound, Amtrak), bus, train, or car

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There are 7 ways to get from Myrtle Beach to Lafayette by plane, shuttle, bus (Greyhound, Amtrak), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Indianapolis, shuttle

    best
    1. Fly from Myrtle Beach (MYR) to Indianapolis (IND)plane plane MYR - IND
    2. Take a shuttle bus from Indianapolis Airport to Holiday Inn City Centreshuttle bus
    5h 33m
    $111–529

  2. Bus

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Lafayette Amtrak Stationbus bus
    24h 5m
    $150–310

  3. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Alexandriatrain train
    3. Take the train from Alexandria to Lafayette Amtrak Stationtrain train
    33h 38m
    $425–908

  4. Drive 777.6 mi

    1. Drive from Myrtle Beach to Lafayettecar car 777.6 mi
    14h 29m
    $142–205

  5. Fly to Chicago Midway International Airport, train

    1. Fly from Myrtle Beach (MYR) to Chicago Midway International Airport (MDW)plane plane MYR - MDW
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    7h 9m
    $117–452

  6. Bus, train via Ironville

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the bus from Fayetteville to Winston-Salembus bus
    3. Take the bus from Winston Salem(Trans Center) to Ashlandbus bus
    4. Take the train from Ashland Amtrak Station to Lafayette Amtrak Stationtrain train
    30h 52m
    $218–456

  7. Bus, train #2

    1. Take the bus from Myrtle Beach Bus Station to Raleigh Bus Stationbus bus
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    40h 16m
    $445–962

Myrtle Beach to Lafayette by bus

Calendar7Weekly Buses
Duration24h 5mAverage Duration
Ticket$150Cheapest Price
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Questions & Answers

Map of how to get from Myrtle Beach to Lafayette.ExpandLaunch map view
  • Distance: 654.8 mi
  • Duration: 5h 33m

What companies run services between Myrtle Beach, SC, USA and Lafayette, IN, USA?

You can take a bus from Myrtle Beach Bus Station to Lafayette Amtrak Station via Atlanta Bus Station and Indianapolis Union Station in around 24h 5m.

Airlines
Train operators
Bus operators

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