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How to get fromMyrtle Beach to Lexingtonby bus (Greyhound), car, or plane

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There are 4 ways to get from Myrtle Beach to Lexington by bus (Greyhound), car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Myrtle Beach Bus Station to Camdenbus bus Greyhound US0641
    2. Take the bus from Camden to Columbia, SCbus bus Nyc
    5h 10m
    $77–115

  2. Drive 150.2 mi

    cheapest
    1. Drive from Myrtle Beach to Lexingtoncar car 150.2 mi
    3h 20m
    $28–40

  3. Fly

    1. Fly from Myrtle Beach (MYR) to Columbia (CAE)plane plane MYR - CAE
    3h 37m
    $135–699

  4. Bus via Sumter

    1. Take the bus from Myrtle Beach Bus Station to Sumter Bus Stopbus bus Greyhound US0645S
    2. Take the bus from James E Clyburn Intermodal Transportation Center to Laurel Sumter Eastbus bus 44
    10h 29m
    $74–117

Myrtle Beach (MYR) to Columbia (CAE) flights

Calendar89Weekly Planes
Duration4h 38mAverage Duration
Ticket$98Cheapest Price
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Questions & Answers

Map of how to get from Myrtle Beach to Lexington.ExpandLaunch map view
  • Distance: 159.7 mi
  • Duration: 5h 10m

What companies run services between Myrtle Beach, SC, USA and Lexington, SC, USA?

You can take a bus from Myrtle Beach Bus Station to Lexington via Camden and Columbia, SC in around 5h 10m. Alternatively, American Airlines, Delta, and United Airlines fly from Myrtle Beach (MYR) to Columbia (CAE) hourly.

Airlines
Bus operators

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Need to know: Greyhound

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