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How to get fromMyrtle Beach to Louisvilleby plane, bus (Greyhound, Flixbus, Amtrak), car, bus, or bus (Greyhound)

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There are 6 ways to get from Myrtle Beach to Louisville by plane, bus (Greyhound, Flixbus, Amtrak), car, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Louisville International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Louisville International Airport (SDF)plane plane MYR - SDF
    4h 43m
    $88–457

  2. Bus via Atlanta

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville to Louisville, KYbus bus
    18h 50m
    $124–235

  3. Drive 609.6 mi

    1. Drive from Myrtle Beach to Louisvillecar car 609.6 mi
    12h 30m
    $112–161

  4. Fly to Blue Grass Airport, drive

    1. Fly from Myrtle Beach (MYR) to Blue Grass Airport (LEX)plane plane MYR - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    4h 50m
    $135–683

  5. Fly to Covington, bus

    1. Fly from Myrtle Beach (MYR) to Covington (CVG)plane plane MYR - CVG
    2. Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus bus
    5h 37m
    $463–711

  6. Bus

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the bus from Fayetteville to Winston-Salembus bus
    3. Take the bus from Winston Salem(Trans Center) to Columbus - Mound Stbus bus
    4. Take the bus from Columbus - Downtown - Mound St to Louisville, KY Bus Stationbus bus
    29h 25m
    $141–311

Myrtle Beach to Louisville by bus

Calendar7Weekly Buses
Duration18h 50mAverage Duration
Ticket$124Cheapest Price
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Questions & Answers

Map of how to get from Myrtle Beach to Louisville.ExpandLaunch map view
  • Distance: 500.9 mi
  • Duration: 4h 43m

What companies run services between Myrtle Beach, SC, USA and Louisville, KY, USA?

Southwest Airlines, American Airlines, and Delta fly from Myrtle Beach (MYR) to Louisville International Airport (SDF) every 4 hours. Alternatively, you can take a bus from Myrtle Beach Bus Station to Louisville, KY via Atlanta Bus Station and Nashville in around 18h 50m.

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