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How to get fromMyrtle Beach to Millsboroby plane, bus (Greyhound), bus, train, car, or shuttle

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There are 7 ways to get from Myrtle Beach to Millsboro by plane, bus (Greyhound), bus, train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Salisbury–Ocean City–Wicomico Regional Airport

    best
    1. Fly from Myrtle Beach (MYR) to Salisbury–Ocean City–Wicomico Regional Airport (SBY)plane plane MYR - SBY
    4h 36m
    $422–764

  2. Drive 450.8 mi

    cheapest
    1. Drive from Myrtle Beach to Millsborocar car 450.8 mi
    9h 28m
    $83–119

  3. Bus

    1. Take the bus from Myrtle Beach Bus Station to Norfolkbus bus
    2. Take the bus from Norfolk, VA - Best Square to Dover Downs Hotel & Casinobus bus
    3. Take the bus from Dover Transit Center to Lewes Transit Centerbus bus 307
    17h 41m
    $116–182

  4. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Wilmingtontrain train
    3. Take the bus from Wilmington Tc to Rehoboth P-N-R @ Country Club Rdbus bus 305
    19h 56m
    $213–440

  5. Fly to Philadelphia International Airport, shuttle

    1. Fly from Myrtle Beach (MYR) to Philadelphia International Airport (PHL)plane plane MYR - PHL
    2. Take a shuttle bus from Philadelphia Airport to Lewes Transit Centershuttle bus
    6h 37m
    $160–520

  6. Bus, train via Washington

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the bus from Fayetteville Bus Station to Washington Union Stationbus bus
    3. Take the train from Washington Union Station to Wilmingtontrain train
    4. Take the bus from Wilmington Tc to Rehoboth P-N-R @ Country Club Rdbus bus 305
    22h 36m
    $169–888

  7. Bus, train via Fayetteville

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the train from Fayetteville Amtrak Station to Wilmingtontrain train
    3. Take the bus from Wilmington Tc to Rehoboth P-N-R @ Country Club Rdbus bus 305
    23h 18m
    $210–418

Myrtle Beach to Millsboro by bus and train

Calendar12Weekly Services
Duration19h 56mAverage Duration
Ticket$213Cheapest Price
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Questions & Answers

Map of how to get from Myrtle Beach to Millsboro.ExpandLaunch map view
  • Distance: 401.5 mi
  • Duration: 4h 36m

What companies run services between Myrtle Beach, SC, USA and Millsboro, DE, USA?

American Airlines, Breeze Airways, and Frontier Airlines fly from Myrtle Beach (MYR) to Salisbury–Ocean City–Wicomico Regional Airport (SBY) 4 times a day. Alternatively, you can take a bus from Myrtle Beach Bus Station to Monroe St At Brandywine Village Apts via Norfolk, VA - Best Square, Dover Downs Hotel & Casino, Delaware State University, Dover Transit Center, Lewes Transit Center, and Rehoboth P-N-R @ Country Club Rd in around 17h 41m.

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