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How to get fromMyrtle Beach to Panama Cityby plane, bus, or car

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There are 6 ways to get from Myrtle Beach to Panama City by plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Northwest Florida Beaches International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Northwest Florida Beaches International Airport (ECP)plane plane MYR - ECP
    4h 11m
    $132–424

  2. Fly to Dothan Regional Airport, drive

    cheapest
    1. Fly from Myrtle Beach (MYR) to Dothan Regional Airport (DHN)plane plane MYR - DHN
    2. Drive from Dothan Regional Airport (DHN) to Panama Citycar car
    7h 32m
    $83–348

  3. Bus, drive

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to La Grange Bus Stationbus bus
    3. Take the bus from La Grange Bus Station to Mobilebus bus
    4. Take the bus from Loxley to Crestviewbus bus
    5. Drive from Crestview to Front Beach Rd. & Back Beach Rd.car car
    22h 17m
    $189–288

  4. Drive 532.5 mi

    1. Drive from Myrtle Beach to Panama Citycar car 532.5 mi
    10h 58m
    $98–141

  5. Fly to Destin–Fort Walton Beach Airport, drive

    1. Fly from Myrtle Beach (MYR) to Destin–Fort Walton Beach Airport (VPS)plane plane MYR - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama Citycar car
    5h 18m
    $84–362

  6. Fly to Tallahassee, drive

    1. Fly from Myrtle Beach (MYR) to Tallahassee (TLH)plane plane MYR - TLH
    2. Drive from Tallahassee (TLH) to Panama Citycar car
    5h 42m
    $99–450

Myrtle Beach (MYR) to Northwest Florida Beaches International Airport (ECP) flights

Calendar47Weekly Planes
Duration4h 57mAverage Duration
Ticket$59Cheapest Price
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Questions & Answers

Map of how to get from Myrtle Beach to Panama City.ExpandLaunch map view
  • Distance: 489.5 mi
  • Duration: 4h 11m

What companies run services between Myrtle Beach, SC, USA and Panama City, FL, USA?

Delta, American Airlines, and Southwest Airlines fly from Myrtle Beach (MYR) to Northwest Florida Beaches International Airport (ECP) every 4 hours.

Airlines
Bus operators

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