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How to get fromMyrtle Beach to Sanibel Islandby plane, bus, train, or car

Find Transport to Sanibel Island

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There are 6 ways to get from Myrtle Beach to Sanibel Island by plane, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Myrtle Beach to Ft. Myers

    best
    1. Fly from Myrtle Beach (MYR) to Ft. Myers (RSW)plane plane MYR - RSW
    4h 35m
    $427–704

  2. Drive 640.6 mi

    cheapest
    1. Drive from Myrtle Beach to Sanibel Islandcar car 640.6 mi
    12h 10m
    $117–169

  3. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Orlandotrain train
    3. Take the bus from Orlando to Fort Myers Amtrak Bus Stopbus bus
    18h 48m
    $280–499

  4. Bus to Wilmington International Airport, fly to Ft. Myers

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Fly from Wilmington International Airport (ILM) to Ft. Myers (RSW)plane plane ILM - RSW
    5h 22m
    $331–680

  5. Fly Myrtle Beach to Fort Lauderdale–Hollywood International Airport, bus

    1. Fly from Myrtle Beach (MYR) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane MYR - FLL
    2. Take the bus from Fort Lauderdale International Airport to Fort Myers Bus Stopbus bus
    5h 57m
    $228–584

  6. Bus, train via Cape Coral Transfer Center

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Winter Park Amtrak Stationtrain train
    3. Take the bus from Orlando to Fort Myers Bus Stopbus bus
    21h 9m
    $218–414

Myrtle Beach (MYR) to Ft. Myers (RSW) flights

Calendar46Weekly Planes
Duration4h 42mAverage Duration
Ticket$78Cheapest Price
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Questions & Answers

Map of how to get from Myrtle Beach to Sanibel Island.ExpandLaunch map view
  • Distance: 549 mi
  • Duration: 4h 35m

What companies run services between Myrtle Beach, SC, USA and Sanibel Island, FL, USA?

Delta, American Airlines, and Southwest Airlines fly from Myrtle Beach (MYR) to Ft. Myers (RSW) every 4 hours.

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Train operators
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