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How to get fromMyrtle Beach to Sioux Fallsby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 5 ways to get from Myrtle Beach to Sioux Falls by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Myrtle Beach (MYR) to Sioux Falls (FSD)plane plane MYR - FSD
    6h 59m
    $109–476
  2. Bus

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Kansas City Bus Stationbus bus
    4. Take the bus from Kansas City to Sioux Fallsbus bus
    37h 48m
    $299–460
  3. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Petersburg Amtrak Stationtrain train
    3. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    5. Take the bus from Minneapolis to Sioux Fallsbus bus
    2d
    $1,008–1,605
  4. Drive  1,428 mi

    1. Drive from Myrtle Beach to Sioux Fallscar car 1,428 mi
    26h 35m
    $245–353
  5. Bus, train via Kansas City

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Savannah Stationtrain train
    3. Take the train from Savannah Station to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to Kansas Citytrain train
    5. Take the bus from Kansas City to Sioux Fallsbus bus
    2d 9h
    $1,158–1,839

Myrtle Beach (MYR) to Sioux Falls (FSD) flights

Calendar38Weekly Planes
Duration7h 27mAverage Duration
Ticket$95Cheapest Price
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Comparing Your Travel Options

What companies run services between Myrtle Beach, SC, USA and Sioux Falls, SD, USA?

American Airlines, Delta, and three other airlines fly from Myrtle Beach (MYR) to Sioux Falls (FSD) 5 times a day. Alternatively, you can take a bus from Myrtle Beach Bus Station to The Bus Stop via Atlanta Bus Station, St Louis Bus Station, Kansas City Bus Station, Kansas City, Sioux Falls, and Maple/Career NE corner in around 37h 48m.

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Want to know more about travelling around United States

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Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

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