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How to get fromMyrtle Beach to Sioux Fallsby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 5 ways to get from Myrtle Beach to Sioux Falls by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Myrtle Beach

    best
    1. Fly from Myrtle Beach (MYR) to Sioux Falls (FSD)plane plane MYR - FSD
    7h 36m
    $109–466

  2. Bus

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Kansas City Bus Stationbus bus
    4. Take the bus from Kansas City to Sioux Fallsbus bus
    37h 48m
    $269–494

  3. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Savannah Stationtrain train
    3. Take the train from Savannah Station to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to Kansas Citytrain train
    5. Take the bus from Kansas City to Sioux Fallsbus bus
    2d 9h
    $627–1,352

  4. Drive  1,449.4 mi

    1. Drive from Myrtle Beach to Sioux Fallscar car 1,449.4 mi
    25h 45m
    $265–383

  5. Bus to Wilmington International Airport, fly

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Fly from Wilmington International Airport (ILM) to Sioux Falls (FSD)plane plane ILM - FSD
    10h 34m
    $128–532

Myrtle Beach (MYR) to Sioux Falls (FSD) flights

Calendar34Weekly Planes
Duration7h 6mAverage Duration
Ticket$97Cheapest Price
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Questions & Answers

Map of how to get from Myrtle Beach to Sioux Falls.ExpandLaunch map view
  • Distance: 1,184.3 mi
  • Duration: 7h 36m

What companies run services between Myrtle Beach, SC, USA and Sioux Falls, SD, USA?

Delta, American Airlines, and two other airlines fly from Myrtle Beach (MYR) to Sioux Falls (FSD) 5 times a day. Alternatively, you can take a bus from Myrtle Beach Bus Station to The Bus Stop via Atlanta Bus Station, St Louis Bus Station, Kansas City Bus Station, Kansas City, Sioux Falls, and Maple/Career NE corner in around 37h 48m.

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