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How to get fromMyrtle Beach to Sioux Fallsby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 7 ways to get from Myrtle Beach to Sioux Falls by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Myrtle Beach

    best
    1. Fly from Myrtle Beach (MYR) to Sioux Falls (FSD)plane plane MYR - FSD
    7h 14m
    $114–466

  2. Bus

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Omaha, NEbus bus
    4. Take the bus from Omaha to Sioux Fallsbus bus
    42h 53m
    $297–559

  3. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Petersburg Amtrak Stationtrain train
    3. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to Detroit Lakes Amtrak Stationtrain train
    5. Take the bus from Detroit Lakes to Fargobus bus
    6. Take the bus from Fargo to Sioux Fallsbus bus
    2d 4h
    $702–1,412

  4. Drive 1,449.4 mi

    1. Drive from Myrtle Beach to Sioux Fallscar car 1,449.4 mi
    25h 45m
    $265–383

  5. Bus to Wilmington International Airport, fly

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Fly from Wilmington International Airport (ILM) to Sioux Falls (FSD)plane plane ILM - FSD
    9h 37m
    $139–523

  6. Bus via Minneapolis

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Minneapolis Bus Stationbus bus
    4. Take the bus from Minneapolis to Sioux Fallsbus bus
    43h 18m
    $302–574

  7. Bus via Saint Cloud

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Saint Cloudbus bus
    4. Take the bus from St. Cloud to Sioux Fallsbus bus
    45h 48m
    $312–564

Myrtle Beach (MYR) to Sioux Falls (FSD) flights

Calendar38Weekly Planes
Duration7h 48mAverage Duration
Ticket$102Cheapest Price
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Questions & Answers

Map of how to get from Myrtle Beach to Sioux Falls.ExpandLaunch map view
  • Distance: 1,184.3 mi
  • Duration: 7h 14m

What companies run services between Myrtle Beach, SC, USA and Sioux Falls, SD, USA?

American Airlines, Delta, and two other airlines fly from Myrtle Beach (MYR) to Sioux Falls (FSD) 5 times a day. Alternatively, you can take a bus from Myrtle Beach Bus Station to The Bus Stop via Atlanta Bus Station, Chicago Bus Station, Omaha, Sioux Falls, and Maple/Career NE corner in around 42h 53m.

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