There are 3 ways to get from Myrtle Beach to St. Louis by plane, bus (Greyhound, Flixbus), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from Myrtle Beach (MYR) to Lambert–St. Louis International Airport (STL)plane MYR - STL
2h 59m$105–507Bus
- Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus Greyhound US0641S
- Take the bus from Atlanta Bus Station to St Louis Bus Stationbus FlixBus N2521
20h 16m$151–247Drive 881.1 mi
- Drive from Myrtle Beach to St. Louiscar 881.1 mi
15h 32m$161–233
Myrtle Beach to St. Louis by bus
Comparing Your Travel Options
The cheapest way to get from Myrtle Beach to St. Louis is to drive which costs $160 - $240 and takes 15h 32m.
The fastest way to get from Myrtle Beach to St. Louis is to fly which takes 2h 59m and costs $100 - $550.
No, there is no direct bus from Myrtle Beach station to St. Louis station. However, there are services departing from Myrtle Beach Bus Station and arriving at St Louis Bus Station via Atlanta Bus Station. The journey, including transfers, takes approximately 20h 16m.
The distance between Myrtle Beach and St. Louis is 748 miles. The road distance is 886.2 miles.
The best way to get from Myrtle Beach to St. Louis without a car is to bus which takes 20h 16m and costs $150 - $250.
It takes approximately 2h 59m to get from Myrtle Beach to St. Louis, including transfers.
Myrtle Beach to St. Louis bus services, operated by Greyhound USA, depart from Myrtle Beach Bus Station.
The best way to get from Myrtle Beach to St. Louis is to fly which takes 2h 59m and costs $100 - $550. Alternatively, you can bus, which costs $150 - $250 and takes 20h 16m.
Myrtle Beach to St. Louis bus services, operated by Greyhound USA, arrive at Atlanta Bus Station.
St. Louis is 1h behind Myrtle Beach. It is currently 4:15 AM in Myrtle Beach and 3:15 AM in St. Louis.
What companies run services between Myrtle Beach, SC, USA and St. Louis, MO, USA?
Southwest Airlines, American Airlines, and Delta fly from Myrtle Beach (MYR) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Myrtle Beach Bus Station to St Louis Bus Station via Atlanta Bus Station in around 20h 16m.
- Website
- aa.com
Flights from Myrtle Beach to Lambert–St. Louis International Airport via Charlotte
- Ave. Duration
- 4h 19m
- When
- Thursday, Friday, Sunday, Monday, Tuesday, and Wednesday
- Estimated price
- $90–490
- Website
- southwest.com
Flights from Myrtle Beach to Lambert–St. Louis International Airport
- Ave. Duration
- 2h 10m
- When
- Saturday
- Estimated price
- $90–490
Flights from Myrtle Beach to Lambert–St. Louis International Airport via Nashville
- Ave. Duration
- 3h 55m
- When
- Tuesday and Wednesday
- Estimated price
- $90–500
Flights from Myrtle Beach to Lambert–St. Louis International Airport via Chicago Midway
- Ave. Duration
- 4h 25m
- When
- Monday, Thursday, and Friday
- Estimated price
- $110–550
Flights from Myrtle Beach to Lambert–St. Louis International Airport via Baltimore
- Ave. Duration
- 4h 33m
- When
- Saturday, Monday, Thursday, and Friday
- Estimated price
- $120–600
- Website
- delta.com
Flights from Myrtle Beach to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 4h 33m
- When
- Every day
- Estimated price
- $95–550
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Myrtle Beach Bus Station to Atlanta Bus Station
- Ave. Duration
- 8h 55m
- Frequency
- Once daily
- Estimated price
- $65–100
- Website
- Greyhound
Bus from Atlanta Bus Station to St Louis Bus Station
- Ave. Duration
- 11h 40m
- Frequency
- Once daily
- Estimated price
- $95–150
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Atlanta Bus Station to St Louis Bus Station
- Ave. Duration
- 10h 21m
- Frequency
- 5 times a week
- Estimated price
- $85–130
- Schedules at
- Flixbus USA
Want to know more about travelling around United States
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Booking & Getting There
Yes, the driving distance between Myrtle Beach to St. Louis is 886 miles. It takes approximately 15h 32m to drive from Myrtle Beach to St. Louis.
Book your Myrtle Beach to St. Louis bus tickets online with Omio and FlixBus.
There are 569+ hotels available in St. Louis.



