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How to get fromMyrtle Beach to St. Louisby plane, bus (Greyhound, Flixbus, Amtrak), car, or bus (Greyhound, Flixbus)

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There are 4 ways to get from Myrtle Beach to St. Louis by plane, bus (Greyhound, Flixbus, Amtrak), car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Myrtle Beach (MYR) to Lambert–St. Louis International Airport (STL)plane plane MYR - STL
    2h 54m
    $115–567

  2. Bus via Carbondale

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Carbondale Intermodal Stationbus bus
    3. Take the bus from Carbondale to St. Louisbus bus
    21h 16m
    $136–275

  3. Drive 881.1 mi

    1. Drive from Myrtle Beach to St. Louiscar car 881.1 mi
    15h 32m
    $161–233

  4. Bus

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus Greyhound US0641S
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus Greyhound US0186
    21h 35m
    $142–275

Myrtle Beach to St. Louis by bus

Calendar5Weekly Buses
Duration21h 16mAverage Duration
Ticket$136Cheapest Price
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Questions & Answers

Map of how to get from Myrtle Beach to St. Louis.ExpandLaunch map view
  • Distance: 743.3 mi
  • Duration: 2h 54m

What companies run services between Myrtle Beach, SC, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and American Airlines fly from Myrtle Beach (MYR) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Myrtle Beach Bus Station to St. Louis via Atlanta Bus Station and Carbondale in around 21h 16m.

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