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How to get fromMystic to Buffaloby train, plane, train (Amtrak), bus, or car

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There are 10 ways to get from Mystic to Buffalo by train, plane, train (Amtrak), bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Boston Logan Airport, fly to Buffalo Niagara International Airport

    best
    1. Take the train from Mystic Station to Bostontrain train
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    5h 57m
    $115–568

  2. Train, bus

    cheapest
    1. Take the train from Mystic Station to Old Saybrook Amtrak Stationtrain train
    2. Take the bus from Old Saybrook Trans Cntr to Asylum St @ Union Plbus bus 921
    3. Take the bus from Hartford to Springfieldbus bus
    4. Take the bus from Springfield Union Station to Buffalobus bus
    13h 29m
    $69–144

  3. Train (Amtrak)

    1. Take the train from Mystic Station to Ny Moynihan Train Hall At Penn Stationtrain train Northeast Regional
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train Empire Service / ...
    12h 38m
    $146–340

  4. Train, bus via New York

    1. Take the train from Mystic Station to Ny Moynihan Train Hall At Penn Stationtrain train Northeast Regional
    2. Take the bus from New York Midtown to Buffalobus bus FlixBus 2686 / ...
    12h 38m
    $96–190

  5. Drive  441.7 mi

    1. Drive from Mystic to Buffalocar car 441.7 mi
    8h 7m
    $81–117

  6. Train, train to Laguardia Airport, fly to Buffalo Niagara International Airport

    1. Take the train from Mystic Station to Stamford Amtrak Stationtrain train
    2. Take the train from Stamford to 125th Street - Harlemtrain train
    3. Fly from Laguardia Airport (LGA) to Buffalo Niagara International Airport (BUF)plane plane LGA - BUF
    7h 23m
    $126–686

  7. Train to John F. Kennedy International Airport, fly to Buffalo Niagara International Airport

    1. Take the train from Mystic Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from John F. Kennedy International Airport (JFK) to Buffalo Niagara International Airport (BUF)plane plane JFK - BUF
    7h 20m
    $116–542

  8. Train to Newark Liberty International Airport, fly to Buffalo Niagara International Airport

    1. Take the train from Mystic Station to Newark Liberty International Airporttrain train
    2. Fly from Newark Liberty International Airport (EWR) to Buffalo Niagara International Airport (BUF)plane plane EWR - BUF
    7h 35m
    $106–550

  9. Train to Boston Logan Airport, fly to Rochester, bus

    1. Take the train from Mystic Station to Bostontrain train
    2. Fly from Boston Logan Airport (BOS) to Rochester (ROC)plane plane BOS - ROC
    3. Take the bus from Rochester Bus Stop to Buffalobus bus
    7h 21m
    $157–707

  10. Train, train to Laguardia Airport, fly to Rochester, bus

    1. Take the train from Mystic Station to Stamford Amtrak Stationtrain train
    2. Take the train from Stamford to 125th Street - Harlemtrain train
    3. Fly from Laguardia Airport (LGA) to Rochester (ROC)plane plane LGA - ROC
    4. Take the bus from Rochester Bus Stop to Buffalobus bus
    8h 42m
    $168–875

Mystic to Buffalo by train (Amtrak)

Calendar21Weekly Trains
Duration12h 38mAverage Duration
Ticket$146Cheapest Price
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Questions & Answers

Map of how to get from Mystic to Buffalo.ExpandLaunch map view
  • Distance: 503.7 mi
  • Duration: 5h 57m

What companies run services between Mystic, CT, USA and Buffalo, NY, USA?

You can take a train from Mystic Station to Buffalo via Ny Moynihan Train Hall At Penn Station in around 12h 38m.

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Train operators
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