Rome2Rio

How to get fromNaperville to Knoxvilleby train, plane, bus, bus (Flixbus), or car

Find Transport to Knoxville

See all options

There are 9 ways to get from Naperville to Knoxville by train, plane, bus, bus (Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Chicago O'Hare International Airport, fly to Mcghee Tyson Airport

    best
    1. Take the train from Naperville to Chicago Union Stationtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS)plane plane ORD - TYS
    4h 55m
    $172–781

  2. Train to Chicago O'Hare International Airport, fly to Chattanooga Metropolitan Airport, drive

    cheapest
    1. Take the train from Naperville to Chicago Union Stationtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Chattanooga Metropolitan Airport (CHA)plane plane ORD - CHA
    3. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    6h 33m
    $75–359

  3. Train, bus

    1. Take the train from Naperville to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    35h 49m
    $428–809

  4. Bus

    1. Take the bus from Chicago Bus Station to New York Midtownbus bus FlixBus N2640 / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    38h 3m
    $329–480

  5. Drive  543.9 mi

    1. Drive from Naperville to Knoxvillecar car 543.9 mi
    9h 39m
    $100–144

  6. Train to Chicago Midway International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Naperville to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Mcghee Tyson Airport (TYS)plane plane MDW - TYS
    4h 46m
    $212–1,031

  7. Train to Chicago O'Hare International Airport, fly to Asheville Regional Airport, drive

    1. Take the train from Naperville to Chicago Union Stationtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Asheville Regional Airport (AVL)plane plane ORD - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    7h 3m
    $84–366

  8. Train, bus via Ossining

    1. Take the train from Naperville to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    36h 27m
    $383–736

  9. Train, bus #2

    1. Take the train from Naperville to Chicago Union Stationtrain train
    2. Take the bus from Chicago Bus Station to New York City Chinatownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    39h 59m
    $244–341

Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS) flights

Calendar76Weekly Planes
Duration1h 57mAverage Duration
Ticket$112Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Naperville to Knoxville.ExpandLaunch map view
  • Distance: 534.9 mi
  • Duration: 4h 55m

What companies run services between Naperville, IL, USA and Knoxville, TN, USA?

You can take a bus from Washington St & Ogden Ave to Knoxville via Yorktown Center, 54th/Cermak Pink Line Station, Jefferson & Harrison, Chicago Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 38h 3m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Booking & Getting There