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How to get fromNaperville to Mayo Clinicby train, plane, bus, or car

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There are 8 ways to get from Naperville to Mayo Clinic by train, plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Chicago O'Hare International Airport, fly to Rochester

    best
    1. Take the train from Naperville to Chicago Union Stationtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    5h 50m
    $48–331

  2. Train, bus via Milwaukee

    1. Take the train from Naperville to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Milwaukeetrain train
    3. Take the bus from Milwaukee to Rochesterbus bus
    10h 21m
    $95–156

  3. Train, bus

    1. Take the train from Naperville to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    12h 8m
    $133–286

  4. Drive  333.3 mi

    1. Drive from Naperville to Mayo Cliniccar car 333.3 mi
    5h 42m
    $61–88

  5. Train to Chicago O'Hare International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from Naperville to Chicago Union Stationtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Minneapolis–Saint Paul International Airport (MSP)plane plane ORD - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 27m
    $299–763

  6. Train to Chicago Midway International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from Naperville to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Minneapolis–Saint Paul International Airport (MSP)plane plane MDW - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 27m
    $134–563

  7. Train, bus #2

    1. Take the train from Naperville to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    10h 50m
    $80–136

  8. Train, bus #3

    1. Take the train from Naperville to Chicago Union Stationtrain train
    2. Take the bus from Chicago Bus Station to Madisonbus bus
    3. Take the bus from Madison to Rochesterbus bus
    11h 26m
    $80–126

Naperville to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration10h 21mAverage Duration
Ticket$95Cheapest Price
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Comparing Your Travel Options

Map of how to get from Naperville to Mayo Clinic.ExpandLaunch map view
  • Distance: 323.8 mi
  • Duration: 5h 50m

What companies run services between Naperville, IL, USA and Mayo Clinic, MN, USA?

There is no direct connection from Naperville to Mayo Clinic. However, you can take the train to Chicago Union Station, walk to Jackson-Blue, take the subway to O'Hare, walk to Chicago O'Hare International Airport (ORD) airport, fly to Rochester (RST), walk to Rochester, take the bus to Rochester, then walk to Mayo Clinic. Alternatively, you can take a train from Naperville to Mayo Clinic via Chicago Union Station, Milwaukee, Milwaukee, and Rochester in around 10h 21m.

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