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How to get fromNaperville to Mayo Clinicby bus, plane, bus (Greyhound, Flixbus), train, or car

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There are 8 ways to get from Naperville to Mayo Clinic by bus, plane, bus (Greyhound, Flixbus), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 330 bus to Chicago O'Hare International Airport, fly to Rochester

    best
    1. Take the bus from La Grange/Burlington Ave. to Rosemont CTA Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    5h 29m
    $53–303

  2. Bus

    1. Take the bus from Naperville to Chicagobus bus
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    10h 10m

  3. Train, bus

    1. Take the train from Naperville to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochester, MNbus bus
    12h 13m
    $163–316

  4. Drive 333.3 mi

    1. Drive from Naperville to Mayo Cliniccar car 333.3 mi
    5h 42m
    $61–88

  5. Fly Chicago O'Hare International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Minneapolis–Saint Paul International Airport (MSP)plane plane ORD - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 4m
    $280–465

  6. Train to Chicago Midway International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from Naperville to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Minneapolis–Saint Paul International Airport (MSP)plane plane MDW - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 27m
    $134–543

  7. Train, bus via Milwaukee

    1. Take the train from Naperville to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Milwaukeetrain train
    3. Take the bus from Milwaukee to Rochesterbus bus
    10h 21m
    $102–161

  8. Bus via Madison

    1. Take the bus from Multi-Modal/Rental Car Facility to 250 N. Lake St - Madison UW Campusbus bus Van Galder
    2. Take the bus from Madison to Rochesterbus bus Jefferson 966 / ...
    10h 24m
    $79–134

Naperville to Mayo Clinic by train, bus, and foot

Calendar21Weekly Services
Duration12h 13mAverage Duration
Ticket$163Cheapest Price
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Questions & Answers

Map of how to get from Naperville to Mayo Clinic.ExpandLaunch map view
  • Distance: 307.6 mi
  • Duration: 5h 29m

What companies run services between Naperville, IL, USA and Mayo Clinic, MN, USA?

You can take a bus from Naperville to Mayo Clinic via Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 10h 10m.

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