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How to get fromNaperville to Saint Charlesby train (Amtrak), bus (Flixbus), car, train, or plane

Find Transport to Saint Charles

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There are 6 ways to get from Naperville to Saint Charles by train (Amtrak), bus (Flixbus), car, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Naperville to Chicago Union Stationtrain train Bnsf
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    8h 24m
    $95–210

  2. Drive  287.7 mi

    cheapest
    1. Drive from Naperville to Saint Charlescar car 287.7 mi
    4h 53m
    $53–76

  3. Bus

    1. Take the bus from Oakbrook Mall to Illinois Terminalbus bus Chicago to Champaign via shopping SB / ...
    2. Take the bus from Champaign Intermodal Trans Ctr to St Louis Bus Stationbus bus FlixBus N2521 / ...
    11h 10m
    $93–131

  4. Train to Chicago O'Hare International Airport, fly

    1. Take the train from Naperville to Chicago Union Stationtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    5h 40m
    $347–735

  5. Train to Chicago Midway International Airport, fly

    1. Take the train from Naperville to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    5h 31m
    $97–535

  6. Train, train to General Mitchell International Airport, fly

    1. Take the train from Naperville to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Milwaukeetrain train
    3. Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane plane MKE - STL
    7h 39m
    $528–949

Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL) flights

Calendar104Weekly Planes
Duration1h 28mAverage Duration
Ticket$52Cheapest Price
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Comparing Your Travel Options

Map of how to get from Naperville to Saint Charles.ExpandLaunch map view
  • Distance: 336.1 mi
  • Duration: 8h 24m

What companies run services between Naperville, IL, USA and Saint Charles, MO, USA?

You can take a train from Naperville to Saint Charles via Chicago Union Station, St. Louis, CIVIC CENTER station, NORTH HANLEY station, North Hanley Transit Center, and 4375 Rider Trail North Sb in around 8h 24m. Alternatively, you can take a bus from Washington St & Ogden Ave to Saint Charles via Yorktown Center, Oakbrook Mall, Illinois Terminal, Champaign Intermodal Trans Ctr, St Louis Bus Station, Civic Center Transit Center, North Hanley Transit Center, and 4375 Rider Trail North Sb in around 11h 10m.

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